Wk18 D3 Chrohn's

Question 1

Crohn's/UC clinical signs
Lesions
Granuloma
Rectal inv
Perianal
Smoking

Answer 1

Skip, transmural/Mucosal, continuous
Pathognomonic/None
Not always/Always
Abscesses/None
Increased risk/Descreased risk

Question 2

CD anatomic distribution
Small bowel alone
Ileocolic
Colon alone

Answer 2

33%
45%
20%

Question 3

4 things that happen to bowel

Answer 3

Inflammation
Obstruction (stricture)
Microperforation
Fistulization (really bad)

Question 4

2 phases of treatment are __ and __. Negative effects is ___.

Answer 4

Induction
Maintenance of remission
Immunosuppression

Question 5

Common rash associated with (not specific for) Crohn’s

Answer 5

Erythema nodosum

Question 6

CD is __% genetic, __% environmental, features an overaggressive ___ immune response

Answer 6

50/50

Th1, Th17-dependent

Question 7

Hygiene hypothesis and role of microbiome in CD.

Answer 7

We’re too clean, so our immune systems become more autoimmune. Antigen pool is abnormal. Ostomy (removing fecal stream) maintains remission.

Question 8

___ cells of innate immune system secreting ___ result in ___. Treatment with mAb can have side-effects of ___.

Answer 8

Macrophage, TNF-alpha
Fever, cachexia, inflammatory cell recruitment
TB, Hep B, lymphoma