Week 9 ch 49 Flashcards
Somatic sensations II. Pain, headache, thermal sensations
Fast pain examples
sharp, prickling, acute, electric feeling
Slow pain examples
burning, aching, throbbing, nauseous, chronic
3 types of nociceptors
- mechanical
- thermal
- chemical
Fast pain nociceptors:
Mechanical, thermal
Slow pain nociceptors:
Mechanical, thermal, chemical
Chemicals that do NOT cause AP (examples and what they do)
- prostaglandins
- substance P
enhance sensitivity but do not excite (do not cause action potential)
Pain receptors and adaptation
do not adapt, excitation becomes progressively greater
Tissue damage does what
activates nociceptors
Pain correlates with
rate at which damage to the tissue is occuring
Tissue ischemia and pain correltaion
greater rate of metabolism, more rapidly pain appears
i.e. blood pressure cuff on still arm or exercising forearem
Pain and metabolism correlation
more metabolic tissue = more pain from ischemia
i.e. muscle spasm: muscle spasm causes compression of blood vessels and causes ischemia, muscle spasm is a high rate of metabolism in that muscle
Fast pain pathway fibers:
A delta
Slow pain pathway fibers;
C
Fast sharp pain signals are elicited by
mechanical or thermal pain
Sudden painful stimulus gives pain sensation on what fibers?
A delta AND C
(“double” pain sensation)
i.e glucose prick = sharp, then dull throbbing pain
Pain fibers terminate on
relay nuerons in DORSAL HORNS
Fast pain signals take the ___ pathway
neospinothalmic tract
Slow pain fibers take the ____ pathway
Paleospinothalmic tract
Fast pain fibers terminate in
lamina I of the dorsal horns
2nd order neurons in the fast pain pathway terminate in
- brain stem
- ventrobasal complex (in thalamus)
What neurotransmitter is at type A delta pain nerve fiber endings?
glutamate
Type C fibers are transmitted via thw
paleospinothalmic pathway
Type C pain fibers terminate in
spinal cord laminae II and III (substantia gelatinosa)
Type C pain fibers cause release of
substance P