Week 7: Systemic Disorders Affecting the Oral Cavity Flashcards
4 phases of hemostasis
- initiation/formation of platelet plug
- coagulation cascade
- termination by antithrombotic control
- removal of clot by fibrinolysis
decrease in number, defective adhesion, defective aggregation
platelet disorders
intrinsic pathway and extrinsic pathway both lead to a _______ that produces _____
final common pathway, fibrin
coagulation disorder
hemophilia
platelet disorders
thrombocytopenia, thrombasthenia
capillary fragility
vitamin C deficiency, hereditary condition
normal bleeding time
between 3-8 minutes
genetic, liver disease, biliary obstruction, steatorrhea, drugs
coagulation factor deficiency
aPTT stands for
activated partial thromboplastin time
normal aPTT values
25-35 seconds
test that identifies acquired or inherited deficiencies in the activities of factors
prothrombin time (PT)
normal values of PT
11-13 seconds
hemophilia:
normal _______
abnormal ____
normal bleeding time, platelet number, prothrombin
abnormal partial thromboplastin time (prolonged clotting time)
hemophilia patients do not develop…
petechiae
thrombocytopenia characteristics (3)
- decreased platelets
- increased destruction
- cirrhosis