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General/Oral Pathology > Week 4: Tissue Repair > Flashcards

Week 4: Tissue Repair Flashcards

1
Q

two ways tissues can be repaired

A

regeneration, scar formation

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2
Q

repair in which tissue is returned to its normal state

A

regeneration

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3
Q

repair in which connective tissue fills in gaps and mends the tissue

A

scar formation (“fibrosis”)

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4
Q

tissues are divided into three groups

A
  1. continuously dividing (labile) tissue
  2. stable tissue
  3. permanent tissue
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5
Q

examples of continuously dividing tissues

A

bone marrow, skin, GI epithelium

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6
Q

continuously dividing tissue:
cells continuously ______
can easily _____ after ____
contain pool of _______

A
  • proliferating
  • regenerate, injury
  • stem cells
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7
Q

stable tissues:

  • cells have ____ to _____
  • can _____, though, if injured
A
  • limited ability, proliferate

- regenerate

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8
Q

examples of stable tissues

A

liver, kidney

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9
Q

permanent tissues:

  • cells ____ ______
  • can’t ______ (so injury always leads to ___)
A
  • can’t proliferate

- can’t regenerate, scar

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10
Q

examples of permanent tissue

A

neurons, cardiac muscle

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11
Q

network that surrounds cells

A

extracellular matrix (ECM)

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12
Q

two forms of ECM

A

interstitial matrix, basement membrane

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13
Q

ECM functions

A

sequesters water/minerals, gives cells scaffold to adhere to, stores growth factor

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14
Q

what cells make collagen?

A

fibroblasts

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15
Q

____ regulates proliferation, movement, and differentiation of the cells living in it

A

ECM

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16
Q

if you screw up the ECM, you (can/can not) regenerate

A

can not

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17
Q

regeneration occurs ____ in labile tissues and occurs _____ in stable tissues

A

all the time, in limited form

18
Q

what happens when you remove one kidney?

A

the other undergoes hypertrophy and hyperplasia

19
Q

what happens when you remove half of a liver?

A

it will grow back

20
Q

in labile tissues, if demand increases, supply ____ _____

A

increases easily

21
Q

4 components to scarring procces

A
  • new vessel formation
  • fibroblast proliferation
  • formation of a collagen scar
  • remodeling of scar
22
Q

term for new vessel formation

A

angiogenesis

23
Q

scarring within the first 24 hours

A
  • endothelial cells start proliferating

- fibroblasts arrive

24
Q

scarring process: 24 hours to few days

A

granulation tissue is formed

25
Q

scarring process: weeks later

A
  • dense fibrosis (scar)

- scar is remodeled over time

26
Q

overview process of scarring (simplified version)

A
  • make granulation tissue

- turn it into a chunk of collagen

27
Q

granulation tissues is made up of 3 things. what are they?

A
  • new blood vessels
  • fibroblasts
  • loose connective tissue
28
Q

true/false, granulation tissue is the same thing as a granuloma

A

false, it is NOT

29
Q

type of healing in which wounds closes easily

A

first intention healing

30
Q

first intention healing

  • ___ wounds
  • ____ _____ predominates over _____
  • healing is ____
A
  • small
  • epithelial regeneration, fibrosis
  • fast
31
Q

examples of first intention healing

A

paper cuts, well-approximated surgical incisions, replaced periodontal flaps

32
Q

did you study the “healing by first intention “ timeline slide?

A

I hope you did! It’s probably going to be exam material!

33
Q

healing that occurs in larger wounds that have gaps between margins

A

second intention healing

34
Q

second intention healing

  • ___ predominates over _______
  • healing is ____
A
  • fibrosis over epithelial regeneration

- slower

35
Q

examples of second intention healing

A

infarction, large burns/ulcers, extraction sockets, gingivectomies

36
Q

second intention healing has…

A
  • more inflammation
  • more granulation tissue
  • wound contraction
37
Q

did you study the “healing by second intention “ timeline slide?

A

I hope you did!!

38
Q

wound strength 3 months after suture removal; does it get back to normal?

A

70-80%, NO

39
Q

there is a ____ ___ in wound strength in the ___ ___ after suture removal

A

rapid increase, four weeks

40
Q

extrinsic factors that lead to bad wound healing?

A

infection, diabetes, steroids; aberrant cell growth

41
Q

aberrant cell growth leads to…

A

keloid scars, proud flesh

General/Oral Pathology (13 decks)

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