Week 5 Study Guide (Pain)(complete) Flashcards

1
Q

identify some of the adjuvant medications (drugs used in addition to primary pain meds) that may be used in the treatment of pain

Meds that are used in conjuction with other meds to help manage pain

A

NSAIDs
Corticosteroids**
Anti-depressants
Anti-convulsant
Local anesthetics
Muscle relaxants
Alpha 2 Adrenergic agonists
NMDA receptor antagonists
Cannabis
Hypnotics and Anxiolytics
Benzodiazepines

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2
Q

Older adults: Pain

A

Numerous myths and misconceptions:
- Fear of addiction
- Impaired cognition/dementia
- Financial
- Pain is NOT part of the normal aging process
- Not all older adults will complain of pain
- Younger nurses afraid to ask about (don’t want to be disrespectful)

*Older Adults
- Risk for respiratory depression, polypharmacy, falls- Age-related changes in absorption, distribution, metabolism, and elimination- Start low, Go slow- Routine bowel regimen

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3
Q

Pregnant/Lactating: Opioid pain management

A

Weigh benefits vs risks
Risk of neonatal opioid withdrawal syndrome
Should avoid opioids while pregnant

If already on opioids, consider methadone or buprenorphine

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4
Q

Opioid receptor: Delta

A

Not fully understood

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5
Q

neurochemicals/transmitters involved in pain: Serotonin
(What does it affect? Which drugs mimics?)

A

Affect: Mood, sleep, appetite

Drug-mimic neurotransmitter: THC, Alcohol, Methamphetamine

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6
Q

What is Nociception and what are the 4 steps?

A

Is the normal function of the physiologic systems that lead to the perception of noxious stimuli as being painful (4-step process)
Transduction
Transmission
Perception
Modulation

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7
Q

Perception

A

Step 3:
Point at which person is aware of pain: threshol is reached (end result)
Activation of high brain stractures
Varies from person to person

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8
Q

Opioid receptor: Kappa

A

Some analgesia, sedation, decreased GI motility
Dysphoria

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9
Q

Opioid receptor: Mu

A

Mu (μ): Primarily pain receptors
Analgesia, respiratory depression, euphoria, decreased GI activity, sedation, and physical dependence

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10
Q

Visceral pain

A

Poorly localized (organ pain)
Deep, aching, cramping, pressure, referred
Activation of nociceptors resulting from stretching, distention, or inflammation
Examples: bowel obstruction, biliary colic

Nociceptive pain

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11
Q

Transmission

A

Step 2:
stimuli move from the peripheral nervous system, to the spinal cord to the ascending tract to the brain.

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12
Q

Drug-mimic neurotransmitter: Endorphins

Chemicals that mimic natural Endorphins

A

Naturally occurring morphine-like substances/Natural pain killer
Ex. Heroin, Opiates, Alcohol

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13
Q

Name the 2 most common side effects of opioids?

A

Respiratory depression and constipation

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14
Q

Nociceptive C-fibers

A

Unmyelinated, small in diameter, and slow-conducting fibers
Transmit dull, aching (visceral) pain that is diffuse

ViCCCCeral

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15
Q

Transduction
(When you drop a DUCE you’re releasing stuff )

A

Step 1:
nociceptors cause the release of serotonin, bradykinin, histamine, substance P, and prostaglandins

Naturally occurring morphine-like substances :
Endorphins
Enkephalins

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16
Q

Enkephalins

A

Naturally occurring morphine-like substances

This is all thats in the power point?

17
Q

Modulation

A

4th Step/Phase of the pain impulse:
-Increasing or increading transmission of pain impulses in the spinal cord

18
Q

What is Chronic pain? (non-malignant)

A

Persistent (>6 months)
Purposeless
May lead to depression
Increases with stress response
Often interferes with sleep
Autonomic adaptation

19
Q

How do Opioid Agonists-Antagonists work

Contraindications?

A

-Bind to more than one opioid receptor site, but block other receptors

-Medications: Buprenorphine (Buprenex; Subutex), Pentazocine (Talwin), and Nalbuphine (Nubain)

-Cause many of the same side effects:
Sedation
Respiratory distress
Constipation
May have more psychotic reactions

-Relief of pain in labor and delivery
-Be careful if patient is on chronic opioid therapy for pain. Can cause withdrawal in these patients

-Careful in COPD
-Those experiencing MI or with severe CAD (cardiac stimulation). Do not give Pentazocine to cardiac patients

-Hepatic and Renal disease

20
Q

neurochemicals/transmitters involved in pain: GABA (think seizures)

A

Effect: Sedation, Anti-anxiety

Drug-mimic neurotransmitter: alcohol, barbituates, benzos

21
Q

How do full opioid Agonists work? Medications and common side effects?

A

*Bind to opioid receptors resulting in activation
-Activation of mu receptors leads to analgesia as well as respiratory depression, euphoria, and sedation
-Activation of the kappa receptors leads to analgesia as well as sedation and decreased GI motility
*Medications:
Morphine, Fentanyl, Codeine, Oxycodone, Hydromorphone, Meperidine, and methadone

*Common side effects:
respiratory depression, constipation, orthostatic hypotension, and urinary retention

*High risk of dependence; are controlled substances

22
Q

Somatic Pain

A

Well-localized
Sharp, aching, throbbing, gnawing
Activation of nociceptors resulting from cutaneous, musculoskeletal, and deep tissues
Examples: Bone pain, soft tissue injury, incisional

Nociceptive pain

23
Q

neurochemicals/transmitters involved in pain:
Dopamine

A

Affect: Reward, stimulation, mood

Drug-mimic neurotransmitter: Cocaine, Heroin, Alcohol
Methamphetamine

24
Q

neurochemicals/transmitters involved in pain: Norephinephrine

A

Affect: mood, sedation, constriction of blood vessels

Drug-mimic neurotransmitter: methamphetamine

25
Q

Nociceptive fibers A-delta

A

Thinly myelinated, large in diameter, and fast-conducting fibers
Transmit sharp, localized (somatosensory) pain that is sensitive to mechanical and thermal stimuli

26
Q

How do Opioid Antagonists work?

A

-Bind tightly to opioid receptors but do not activate them.
-Used to reverse opioids when levels are too high

Drugs:
Naloxone (Narcan, Evzio)
Naltrexone (Revia)

-Work by reversing the effects of opioids:
Respiratory distress
Hemodynamic instability
Over sedation
Those with opioid addiction will experience withdrawal

-Can be given IV, IM, SQ, or as a nasal spray

27
Q

What is Acute pain?

A

Time limited
Cause is usually known
Diminishes over time
May have observable signs, such as:
-Increased blood pressure and/or heart rate
-Agitation
-Guarding

28
Q

Role of Naloxone

A

Opioid antagonist
A nasal spray (narcan) can counteract the effects of an overdose of heroine or other opioids. Nalaxone has a stronger attraction to the brain’s receptors and displaces the opioids long enough to allow breathing to resume.

29
Q

Identify medications in each group

A

Not sure if she means know about individual meds or to just kno what groups they belong in?