Week 4 - Depressive and bipolar disorders Flashcards
________ ___________is primarily characterised by persistent sad, empty or irritable mood accompanied by a range of other features, such as feelings of worthlessness, a sense of failure and low energy.
Depressive disorder
Depressive disorder involving one or more
major depressive
episodes.
major depressive disorder
In ancient Greece, the term ___________ was used to denote a mental condition characterised by fear and depression.
‘melancholia’
German psychiatrist ______ ___________(1896) identified ‘manic depressive insanity’ as one of the major categories of mental illness. Manic depressive insanity encompassed the conditions that are currently categorised as bipolar disorders and depressive disorders.
Emil Kraepelin
_____________ concept was controversial as it classified all disorders of mood together rather than distinguishing between those individuals who experience depressive episodes alone and those who experience both depressive and manic episodes (currently termed depressive
disorders and bipolar disorders, respectively).
Kraepelin’s
The current classification system is founded on work of the German psychiatrist Karl __________ (1957) who made a distinction between depression and bipolar disorder.
Leonhard
DSM-5 includes a chapter entitled ‘Depressive Disorders’. Among these conditions is major depressive disorder, commonly referred to as _______ depression
major
In ICD-10, major depression is known as ________ __________ disorder.
recurrent depressive
__________ ___________ is characterised by a continuous period of at least _______ weeks during which the person feels depressed, sad, empty or hopeless, or has lost interest in nearly all of his/her activities (anhedonia)
Major depression
two
Inability to experience
pleasure from previously
pleasurable activities.
Anhedonia
This period of low mood must represent a change in the person’s functioning and be accompanied by at least ________ of the following symptoms:
∙ significant weight loss when not dieting, or weight gain, or a decrease or increase in appetite nearly every day
∙ insomnia or hypersomnia nearly every day
∙ loss of energy or fatigue nearly every day
∙ motor restlessness (‘psychomotor agitation’) or slowed movements (‘psychomotor retardation’) nearly every day and observable to others
∙ diminished concentration or ability to think, or indecisiveness nearly every day
∙ feelings of worthlessness or excessive or inappropriate guilt nearly every day
∙ recurrent thoughts of death, recurrent suicidal ideation without a plan or a suicide attempt or a
specific plan for committing suicide.
four
(these symptoms also need to cause significant
distress and impairment in the person’s life—impacting on his/her social, occupational and other important roles)
An extension to
the diagnosis used by DSM-5 that further clarifies the course,
severity or special features of the disorder.
specifier
In the case of __________ ___________ disorder, there are several specifiers:
- severity (mild, moderate or severe),
- the number of episodes (single or recurrent),
- the degree of recovery between depressive
episodes (in partial remission or in full remission) and
- whether there are accompanying psychotic
features.
major depressive
Depression in which the person experiences delusions and/or hallucinations is referred to as major depressive disorder with _________ ___________.
psychotic features
Major depressive disorder with _____________ feature is characterised by a profound, nearly complete inability to experience pleasure.
Mood is usually worse in the mornings and the
sufferer may experience early morning awakening, marked psychomotor
retardation or agitation,
significant anorexia (i.e., loss of appetite) or weight loss and. excessive guilt
melancholic
Major depressive disorder with _________ features, is characterised by movement disturbance
symptoms, such as immobility at one extreme or excessive, purposeless activity at the other extreme
catatonic
Women experiencing psychosocial stressors such as a perceived lack of support from their partner, family and friends, feeding and physical difficulties
with the infant, stressful life events, a previous history of depression and complications during pregnancy, are at higher risk of major depressive disorder with ___________onset (during
pregnancy or within four weeks after childbirth).
peripartum
(more serious than postpartum depression known as ‘the baby blues)
Episodes of depressed mood (often referred to as ‘the baby blues’) can occur in up to ______ per cent of women within 1–10 days after childbirth.
70
Major depressive disorder with ___________ pattern, which is diagnosed when there is a regular relationship between the onset of the sufferer’s major depressive episodes and a particular time of the year (most often with onset in the autumn or winter months).
seasonal
Major depressive disorder, accompanied by significant anxiety such as irrational worry, inability to relax or a sense of impending threat is known as major depressive disorder with _______ ________.
anxious distress
Comorbidity between depression and anxiety, is found in about
______ per cent of people with major depressive disorder.
50
The presence of
anxiety in depression
increases the risk of suicide and predicts a longer length of the depressive episode. True/False
True
Patient who experience symptoms better fitting of bereavement are no longer excluded form DSM-5 meaning they can now be diagnosed with major depressive disorder. True/False
True
(The DSM-5 has attempted to minimise the chances of
inappropriately diagnosing bereaved individuals with a mental disorder by listing some distinctions between non-pathological grief and major depression (e.g., a preoccupation with thoughts about the
deceased in the former versus self-critical thoughts in the latter).
DSM-5 replaced dysthymic disorder (less severe but more chronic depression) with __________ depressive disorder to more clearly describes a depressive disorder where the mood disturbance and at least two other symptoms last for more than two years.
persistent
A new diagnostic category introduced in the DSM-5 is disruptive ________ ____________
disorder which is common in children and is characterised by severe and persistent
irritability as evident in temper outbursts that are extremely out of
proportion to the
situation
mood
dysregulation
Diagnosis of disruptive mood dysregulation disorder is highly prevalent in the US
but has been generally viewed sceptically in Europe and Australasia, given similarity with other diagnoses in the DSM-5 where behavioural and emotional
dysregulation are core features (e.g., oppositional defiant disorder, attention-deficit/hyperactivity
disorder, impulse control disorders and bipolar disorder), reliably distinguishing disruptive mood
dysregulation disorder from these conditions could prove challenging. True/False
True
Australian subtyping model suggests three broad classes of depressive disorders: psychotic, melancholic (both biologically based) and non-melancholic (driven by life-event stressors and psychological factors). True/False
True
Depressive disorders are among the most prevalent psychological problems in Australia with higher rates in ________ 5.1% compared to _________ 3.1%.
women
men
Rates of dysthymia are about _____ %for men and ______% for women.
1
1.5
It has been estimated that ______ in 10 Australians
are affected by
someone close to them suffering from a mood disorder
1
Psychological distress in the Australian population has significantly reduced between 1995 and 2011. due to effective treatments. True/False
False
(has not changed despite available treatments)
Depressive disorders in children and adolescents have been steadily increasing/decreasing over the past 5–10 years in most developed countries.
Increasing
(girls have higher rates than boys)
Women are found to be twice as likely to experience depression, this is believed to be due to:
-women talking more readily about it
- biological factors such as hormones
Australian data released in 2015 indicated that _____ per cent of Australian adolescents (aged 12–17
years) had depressive disorders, including major depressive disorder and dysthymia, over a 12-month
period.
5
Depressive disorders can affect people at any age. Onset of a first episode of depression can occur from as young as ______ years of age
3
Median age of onset for mood disorders is about ______ years of age.
30
In Australia, studies have found that approximately _____ per cent of those who experience depression meet criteria by the age of 25.
20
Follow-up studies have demonstrated that up to ______ per cent of those with a depressive disorder will recover within the first six months following treatment. Unfortunately, major depressive disorder
has a highly recurrent character. About 50 per cent of people who recover from a first episode of depression will have no further episodes, but many will have a further episode or not recover fully
from the first episode.
50
The four main problems associated with depression include:
- an increased risk of suicide and suicide
attempts, - difficulties performing occupational and social activities,
- anxiety disorders and 4. physical health
problems.
The rate of suicide in the community from
depressive disorders is estimated to be approximately 3.5 per cent, with a higher preponderance
of _______ suicides (6.9%) over ________ suicides (1.1%)
male
female
Depression is associated with an increased rate of suicide attempts and successful suicide, with
as many as ____ per cent of people who take their own life suffering from depression
75
Suicide rates in Australia appear to have been increasing/declining since the late 1990s?
declining
The aetiology of depression is believed to include a combination of which factors:
- biological,
- psychological,
- social and
- environmental
Genetics play a significant part in the development of depression. True/False
True (yet not well understood and current understandings highlight the interplay between genetic vulnerability and
stressful life events)
(e.g. inherited anxious traits in children may contribute to the development of overprotective or authoritarian parenting styles which may in turn undermine the child’s sense of mastery over
his/her environment, rendering the child vulnerable to developing further anxiety problems and depression.
The main _____________ implicated in depression are serotonin,
noradrenaline (norepinephrine)
and dopamine, which are also involved in the regulation of sleep cycles, motivation and appetite.
neurotransmitters (monoamines)
Catecholamines
(adrenaline,
noradrenaline
and dopamine)
and serotonin belong to a family of neurotransmitters called __________.
monoamines
Monoamines are concentrated in the _________ system, a part of the brain associated with integrating goal-directed activities
limbic
Early theories suggested
that depression was caused by a reduction in the availability of _____________ neurotransmitters in the
synapses between neurons.
monoamine
More recent theories of depression have implicated abnormalities
in the number and sensitivity of receptors available to take up monoamine neurotransmitters in
__________ which then affects the balance of the various available neurotransmitters
synapes
Euroendocrine (hormonal) theories suggest a role for hyperactivity in the hypothalamic-pituitary/adrenal (HPA) axis in the development of depression as HPA axis is critical to the body’s response to
stress and produces stress hormones involved in the fight or flight response. People who are depressed
tend to demonstrate chronic overactivity in the HPA axis, resulting in the production of
excess stress hormones (such as cortisol), which in turn affects the way in which monoamine neurotransmitters work
in the brain.
Neurophysiological theories focus on structural or functional abnormalities in certain structures in the brain such as the pre-frontal cortex, hippocampus, anterior cingulate cortex and the amygdala
Research yet to determine whether
these abnormalities are a cause or a consequence of depression.
Environmental factors, which usually precede depressive episode by 6-9 months, include:
- stressful life events such as financial problems, divorce, break up, loss of a loved one, job loss, abusive relationships…..
Early __________ theories such as the learned helplessness model of depression (Seligman) proposed that depression is a learnt response to adverse events that are perceived (based on the observation that when laboratory animals
were subjected to unavoidable adverse outcomes (i.e., electric shocks) that were independent of their
behaviour (i.e., uncontrollable), they gave up trying to do something about their situation
cognitive
The depressive attributional style is one that interprets negative life events as being
due to internal (the individual’s own fault), global (applicable to all situations) and stable (unchanging or invariable) factors. For example, according to this theory, a person who interprets the ending of a romantic relationship as being due to an aspect of him/herself that
pervades all of his/her relationships
and that cannot be changed will be more likely to experience a sense of hopelessness regarding the possibility of establishing a meaningful relationship in the future and hence will be at risk of developing depression.
(n another major cognitive theory of depression, Aaron Beck proposed that negative
experiences in childhood may result in the development of dysfunctional core beliefs about the _______, ________ and the ________(such as a highly critical parenting style resulting in the child’s belief that s/he is unlovable). Individuals generally deal with these negative core beliefs by adopting compensatory
strategies or rules that protect them from developing depression (e.g., ‘as long as I’m in a relationship
then I’m lovable’).
self,
others
world
= AKA negative cognitive triad
Beck proposes that these negative core beliefs can be triggered by relevant negative life events (e.g., the ending of a relationship activating the belief ‘I am unlovable’) and thus result in a depressive episode. He argues that the thought patterns of depressed people are
characterised by self-criticism, a negative view of others and life events and pessimistic
expectations
regarding the future.
_________ inference takes place when a person draws a conclusion in the absence of
supporting evidence or despite the presence of contradictory evidence (e.g., ‘I did not get invited to Jenny’s
party. That must mean that I have offended her in some way’).
Arbitrary
According to Beck, this negative view of the self, the world and the future (known as the negative cognitive triad) is maintained by a number of cognitive distortions in which depressed
people are likely to engage. Among these errors in thinking are the following:
- Arbitrary inference
- Magnification and minimisation
- Personalisation
- Overgeneralisation
__________ and ___________occur when a person magnifies or exaggerates his/her perceived failures (e.g., ‘I couldn’t answer that question in class. Everyone thinks I am such an idiot’) and
minimises or discounts his/her achievements (e.g., ‘I managed to get a part-time job in the company but they were probably desperate to hire someone’).
Magnification minimisation
A dominant _____________ theory regarding the aetiology and maintenance of
depression proposes that some life events or stresses can reduce the opportunity to experience positive
reinforcers, which in turn increases the risk of depression.
behavioural
(e.g. life events, poor coping skills)
_________________ occurs when a person draws a conclusion based on a single event (e.g., ‘My
boyfriend broke up with me last week. I’m hopeless with
relationships’)
Overgeneralisation
____________ entails relating events to oneself in the absence of any clear evidence (e.g., ‘Terry was frowning when he saw me in the shop. I must have done something to make him angry’).
Personalisation
___________ theories hold that depression is a form of pathological grief
Psychoanalytic
Conditions or variables
associated with a
reduced risk or chance of developing a disorder
protective factors
Family interaction style in which family members are overly
protective and self-sacrificing towards the
person with a psychological
disorder while
also expressing high levels of criticism and
hostility; this may contribute to the
person’s relapse.
expressed emotion (EE) = social factors
____________ include:
- tricyclic antidepressants (TCAs),
- selective serotonin reuptake inhibitors
(SSRIs),
- serotonin
noradrenaline reuptake inhibitors (SNRIs),
- monoamine oxidase inhibitors (MAOIs)
and several other newer medications that do not easily fit into the previous four categories.
Antidepressants
____________ are the most frequently used medications for
depression.
Antidepressants
(work by increasing the availability of neurotransmitters or
increasing the sensitivity of neuron receptors in the brain)
__________
medications are used to
treat psychotic
symptoms such as delusions and
hallucinations.
Antipsychotic
In terms of efficacy, newer forms of antidepressants (such as the SSRIs) were similar
to tricyclic antidepressants for the treatment of depression, however newer meds have a lover dropout rate due to less side effects. True/False
True
_______ ________ ________ ________ (rTMS) is a
biological treatment that
exposes patients to repeated, high-intensity
magnetic pulses that are focused on particular
brain structures in order to stimulate them.
repetitive transcranial magnetic stimulation
(approved in US, further research is required to refine and develop rTMS as a general treatment for depressive disorders)
Biological treatment in
which the vagus nerve (the part of the
autonomic nervous system that carries
information from the head, neck, thorax
and abdomen to several areas of the brain) is
stimulated by a small electronic device similar
to a cardiac pacemaker, which is surgically
implanted under a patient’s skin in the left chest wall.
vagus nerve
stimulation
Treatment that involves
exposure to bright light; used particularly during
the winter months for individuals with seasonal affective
disorder
bright light therapy
(one study showed it to be more effective than pharmacotherapy)
Treatment for mood disorders that involves
the induction of a brain seizure by passing an
electrical current
through the patient’s brain while s/he is
anaesthetised.
electro-convulsive therapy (ECT)
(for severe cases)
ECT is usually delivered to the _________ (right/left) side of the brain to minimise which minimises the
likelihood of long-term memory and learning
problems.
right
________ ________
scheduling is a
behavioural technique
entailing planning
a gradual increase in the
level of pleasant activities the client
engages in as a way of improving his/her mood.
Pleasant activity
A key cognitive technique is __________ restructuring. Here, the client is introduced to the ________ model
in which activating
events trigger dysfunctional beliefs that in turn result in negative consequences
(i.e., negative mood and behaviours)
cognitive
ABC
(IPT)
Short-term psychological treatment
originally developed by
Gerald Klerman,
Myrna Weissman
and their colleagues for
the treatment of depression; addresses
the client’s interpersonal
problems as a way of
improving his/her psychological symptoms.
interpersonal
psychotherapy
(Current treatment guidelines state that IPT is as effective as CBT
in the treatment of moderately severe depression)
Therapies focused on
uncovering and resolving unconscious
conflicts that drive
psychological symptoms.
psychodynamic
therapies