Week 4 - Blood Modifier Medications Flashcards
What types of medication classes prevent clot formation (2)?
- Anticoagulants
- Antiplatelet drugs
What type of medication class removes an existing clot? - lyse
Thrombolytics
What type of medication class promotes clot formation?
Anti-fibrinolytics
the (3) concepts of clotting
pharmacology are:
- PREVENT
- REMOVE
- PROMOTE
Creating a Blood clot is a complex process involving (3) Stages:
- Vasoconstriction
- Platelet clumping (aggregation)
- Coagulation (Cascade of clotting factors)
There are (2) Coagulation pathways where clots are made by adding fibrin to an aggregation of platelets:
- Extrinsic Pathway
- Intrinsic Pathway
________________ will interfere with the Coagulation process of by affecting the clotting factors that make fibrin (reduce
fibrin)
Anticoagulants
______________ drugs will be used to affect the first stage of the clotting process by preventing platelet aggregation.
Antiplatelet
Antifibrinolytics have (2) actions:
- Prevent the lysis of fibrin (STOP LYSIS)
- Reduce blood viscosity (Thicken blood)
Drug Reversal Agents examples (2):
- Heparin sodium antagonist
- Warfarin sodium antagonist
Measuring ______________ it takes blood to clot is the way we measure the effect of Anticoagulant, Antiplatelet therapy
How long
What is PT/INR?
Prothrombin time, international Normalized Ratio
What is aPTT?
Activated partial thromboplastin time
_____ is also an important value but is primarily used
for diagnosis of clotting deficiencies
PTT
Normal PT time values?
11–13 seconds
