Week 3a Glucose Regulation Flashcards
biguanides do not?
increase insulin resistance
Where does blood from the islets drain into?
the hepatic portal vein
Promotes conversion of monosaccharides, lipids and amino acids into storage forms of polysaccharides, triglycerides and proteins
Insulin
Glucagon
promotes conversion of glycogen, proteins and lipids into glucose (gluconeogenesis) and release of glucose into the blood
How do catchecholamines affect blood glucose?
they help to maintain blood glucose levels in times of stress
How does growth hormone affect blood glucose?
increases protein synthesis in all cells of the body, mobilizes fatty acids from adipose tissue and antagonizes the effects of insulin
How do glucocorticoids affect blood glucose?
They are critical to survival during periods of fasting and starvation. They also stimulate gluconeogensis by the liver.
What is the main stimulant for insulin secretion?
high serum glucose
What are the 3 functions of Insulin?
1) glucose uptake by cells
2) facilitates storage of glucose and glycogen and triglycerides
3) Prevents breakdown of other sources
What does a C-peptide level suggest?
It distinguishes between type 1 diabetes or type 2
Why is C-peptide level measured instead of insulin?
can assess a persons own insulin even if they receive injections
Gluconeogenesis
generation of glucose
Glycogenolysis
the breakdown of glycogen
What functions and the beta cell glucose sensor?
Glucokinase
What can mutations in glucokinase lead to?
early onset of mild diabetes (maturity-onset diabetes of the young - MODY)
What is the most potent stimulator of insulin release?
Glucose
Incretin-like drugs for the treatment of type 2 DM, unlike sulfonylureas, are less likely to induce?
hypoglycaemia
What is insulin secretion inhibited by?
catecholamines and somatostatin
Where are the majority of insulin receptors?
liver, muscle and fat tissue
Where are GLUT-4 ?
muscle cells and adipose tissue
GLUT -2
beta cells and liver cells.
GLUT - 1
all tissues, basal glucose uptake. Does not require the actions of insulin. Nervous system.
When does endogenous insulin peak?
35-40 mins post meal
What does endogenous insulin return to baseline after a meal?
2-3 hours
What is diabetes mellitus characterized by?
hyperglycaemia, polydipsia, polyuria and glycosuria
Diagnosis of type 1 DM includes a fasting glucose of?
> 7mmol/L
Type 1A DM involves?
a hypothetical triggering event that involves an environmental agent that incites an immune response
In Type 1B DM, there is no evidence of?
autoimmunity
Which type of people is Type 1B DM most common in?
African or asian descent
Type 1 B DM is strongly?
Inherited
What is the difference between latent autoimmune diabetes of adult hood and Type 1 DM?
LADA occurs when the body stops producing adequate insulin. LADA progresses slowly and insulin may still be produced even after diagnosis
What kind of gene condition is Maturity Onset Diabetes of the Young (MODY)
it is a single gene mutation that disrupts insulin production. It is also a dominant genetic condition
Neonatal DM
a monogenic form of diabetes, like MODY
What are the 3 metabolic abnormalities in Type 2 diabetes?
1) impaired beta cell function and insulin secretion
2) Peripheral insulin resistance
3) Increased hepatic glucose production
What are 3 major causes of beta cell dysfunction in diabetes?
1) Chronic hyperglycaemia that results in beta cell desensitization
2) Chronic elevation of free fatty acids
3) Amyloid deposition in the beta cells
metabolic syndrome
cluster of conditions such as increased blood pressure, excess body fat around the waist and abnormal cholesterol or triglyceride levels
What are some of the signs and symptoms of metabolic syndrome?
- elevated triglycerides
- Low HDL
- HTN
- Systemic inflammation
- Fibrinolysis
- abnormal function of the vascular endothelium
- Macrovascular disease
What are some consequences of reduced glucose uptake?
- lipolysis
- proteolysis
- endothelial dysfunction
How does ketonuria result?
Liver metabolism of excessive amounts of fatty acids which results in ketogenesis and ketonuria