Week 2 Flashcards
What are 2 important effects of Addisons Disease?
Hyponatremia and hyperkalemia
hyper pigmentation is associated with
Addisons Disease
Addisons disease has _____ levels of ACTH
high
what is important to note in a patient who has Addison’s disease when they are to have surgery?
it is recommended to give a stress dose of glucocorticoids before surgery. Preparation for surgery should also include treatment of hypovolemia, hyponatremia and hyperkalemia.
Pharmacotherapy of corticosteroids:
well-absorbed, transported attached to plasma proteins, widely distributed, metabolized by liver and excreted by kidneys
corticosteroids can decrease the effectiveness of?
anti diabetic drugs
what is a major adverse effect of glucocorticoid therapy
Cushing’s syndrome
What is important to note about glucocorticoids and NSAIDS?
They may cause peptic ulcers. Therefore it is important to use a PPI during treatment
what can happen if a corticosteroid is abruptly stopped?
adrenal crisis: hypotension, seizures, renal failure, coma, nausea, vomiting
what is the treatment for adrenal crisis
IV hydrocortisone
Cushings syndrome is also called
hypercortisolism
Most common cause of Cushing’s syndrome
excess secretion of ACTH from the anterior pituitary
what are the 2 main therapies for Cushing’s?
Aminoglutethimide and ketoconazole
what happens to electrolytes with hyperaldosternism?
hypernatremia and hypokalemia
What happens to the BP in hyperaldosteronism?
increased BP
