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Physiology 1 > Week 3 > Flashcards

Week 3 Flashcards

1
Q

Hematocrit HCT

A

F = 0.37 - 0.48 (%)
M = 0.4 - 0.52 (%)

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2
Q

RBC count

A

4.5 - 5 Million per ul

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3
Q

Platelet count

A

150,000 - 300,000 per ul

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4
Q

WBC count

A

4000 - 11,000 per ul

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5
Q

Neutrophil G count

A

40 - 70%
4000 per ul

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6
Q

Eosinophil G count

A

0 - 6%
200 per ul

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7
Q

Basophil G count

A

0 - 2%
50 per ul

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8
Q

Lymphocyte count

A

20 - 50%
2000 per ul

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9
Q

Monocyte count

A

4 - 8%
500 per ul

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10
Q

2 Types of Hematopoiesis

A

Constitutive & Stress

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11
Q

HSC surface markers

A

C-Kit (Stem cell factor receptor)
CD34 (Adhesion Molecule)

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12
Q

Hematopoiesis steps

A

Embryonic SC - LTHSC - STHSC - MPP - CLP/CMP

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13
Q

Cytokine definition

A

Glycoproteins that effect cellular functions
e.g: Erythropoietin

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14
Q

How long does Erythropoiesis take?

A

7 - 10 Days

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15
Q

Steps of Erythropoiesis

A

… - CMP - MEP - Proerythroblast - Basophil EB - Polychromatophil EB - Orthochromatic EB - Reticulocyte - Erythrocyte

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16
Q

What regulates Erythropoiesis and where is it produced

A

Erythropoietin (EPO)
—-> Kidney Cortex

17
Q

What does Hypoxia inducible factor HIF do?

A

Increases transcription of the Erythropoietin gene

18
Q

3 Elements needed for erythropoiesis

A

Iron
Vitamin B12
Folic Acid

19
Q

What happens when Iron is deficient?

A

RBCs small and pale
(Haemoglobin)

20
Q

What happens when B12 and Folic acid are deficient?

A

RBCs Larger, Nucleus present, lower number.
(DNA)

21
Q

Blood type H Gene

A

Fucosyl-transferase

22
Q

Blood type A Antigen

A

N-acetyl-galactosamine (GalNAc)

23
Q

Blood type B Antigen

A

Galactose

24
Q

Blood types O, A, B, AB

A

O: H
A: H A
B: H B
AB: H A B

25
Q

Rh Blood, what makes it positive

A

Having D subunit of Rh
Not everyone has it

26
Q

Thrombopoiesis steps

A

… - CMP - MEP - MkP - Promegakaryoblast - Megakaryoblast

27
Q

Primary Haemostasis

A

Vasoconstriction
Thrombocyte adhesion, activation, aggregation
Thromboxane A2 (TP-R)
Serotonin (5-HT2)
Epinephrine (a1)

28
Q

What causes Platelet Adhesion

A

Von Willebrand Factors
(Surface Integrins)

29
Q

Secondary Haemostasis, Pathways

A

Coagulation / Clotting Factors
Extrinsic & Intrinsic Pathways

30
Q

Main anticoagulants

A

Antithrombin (SERPINC1)
Thrombomodulin
Act. Protein C

31
Q

K+ Nernst Potential

A

-90 mV

32
Q

Na+ Nernst Potential

A

+ 60 mV

33
Q

Ca 2+ Nernst Potential

A

+ 120 mV

34
Q

Cl- Nernst Potential

A

-70 mV

35
Q

What is Na/K ATPase Inhibitor?

A

Ouabain

Physiology 1 (12 decks)

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