Week 2 Thrombolytics

Question 1

What is the goal of Thrombolytic medications?

Answer 1

Maintain or restore circulation

Question 2

What are the three types of thrombolytic medications?

Answer 2

• Anticoagulants
• Antithrombotics
• Thrombolytics

Question 3

What do Anticoagulants do?

Answer 3

Prevent the formation of clots which impede circulation

Question 4

What do Antithrombotics do?

Answer 4

-AKA antiplatelets

Prevent platelet aggrigation

Question 5

What do thrombolytics do?

Answer 5

Break up clots that have already formed

Question 6

What are the four main classes of anticoagulants?

Answer 6

• Coumarins
• Factor Xa inhibitors
• Heparins
• Thrombin inhibitors

Question 7

What is the most common Coumarin medication?

Answer 7

Coumadin

Question 8

What is the basic MOA of Coumarin medications?

Answer 8

The inhibition of Vitamin K

Question 9

What is the antidote for Coumarin medications?

Answer 9

Vitamin K, Fresh frozen plasma

Question 10

Factor Xa inhibitors end in what suffix?

Answer 10

-xaban

Question 11

What are the two common factor Xa inhibitors?

Answer 11

rivaroxaban

apixaban

Question 12

What is the basic MOA of Factor Xa inhibitors?

Answer 12

Inhibits Factor Xa in clots and blood

Question 13

Heparin medications end in what suffix?

Answer 13

-parin

Question 14

What are the three common heparin medications?

Answer 14

• enoxaparin
• heparin
• dalteparin

Question 15

What is the basic MOA of heparin medications?

Answer 15

Activates antithrombin III

Question 16

What is the antidote to heparin medications?

Answer 16

protamine sulfate

Question 17

Thrombin inhibitors end in what suffix?

Answer 17

-an

Question 18

What are the two common thrombin inhibitors?

Answer 18

• dabigatran

- argatroban

Question 19

What is the basic MOA of thrombin inhibitors?

Answer 19

They bind to and inhibit thrombin

Question 20

What is the main goal of antiplatelet medications?

Answer 20

prevent thrombosis in arteries

Question 21

What are the three main antiplatelet medications/medication types?

Answer 21

• Aspirin
• ADP receptor blockers
• Glycoprotein IIb/IIIa receptor blockers

Question 22

What is the MOA of aspirin r/t its antiplatelet action?

Answer 22

irreversibly binds to cyclooxygenase in platelets, inhibiting thromboxane2 formation

Question 23

What is the MOA for ADP receptor blockers

Answer 23

irreversible alteration of the platelet plasma membrane, unable to receive signals for aggrigation

Question 24

What are the two common ADP receptor blockers?

Answer 24

• ticlopidine

- clopidogrel

Question 25

What is the MOA for Glycoprotein IIb/IIIa receptor blockers?

Answer 25

interferes with the enzyme involved in aggregation

Question 26

What are the three common Glycoprotein IIb/IIIa receptor blockers?

Answer 26

- abciximab - eptifibatide - triofiban

Question 27

What is the main goal of thrombolytic medications?

Answer 27

To promote the conversion of plasminogen to plasmin

Question 28

Thrombolytic drugs end in what suffix?

Answer 28

-ase

Question 29

What are the common thrombolytic medications?

Answer 29

-Streptokinase -Urokinase -Alteplase tPA -Reteplase rPA Tenecteplase TNK-tPA

Question 30

What are the major considerations for anticoagulant medications?

Answer 30

- Assess for Bleeding or signs of internal bleeding - Assess clotting studies - Assess for drug-drug or drug-food interactions

Question 31

What are the major considerations for antithrombotic medications?

Answer 31

- Assess for Bleeding or signs of internal bleeding - Assess clotting studies - Assess for a history of thrombocytopenia