Week 2 Antihyperlipidemics

Question 1

What is the main goal of antihyperlipidemic medications?

Answer 1

To reduce high blood lipid levels while supporting good lipids

Question 2

What are the 5 main antihyperlipidemic medication classes?

Answer 2

• Bile sequestrants
• Fibrates (fibric acid)
• Nicotinic acid
• Cholesterol absorption inhibitors
• Hepatic 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (Statins)

Question 3

What are the three main Bile sequestrants?

Contain “coles/choles”

Answer 3

• cholestyramine
• colestipol
• colesevelam

Question 4

What is the MOA of bile sequestrants?

Answer 4

Bind with bile acids in the intestines

Question 5

What is the main Fibrate medication?

contains fibro

Answer 5

gemfibrozil

Question 6

What is a major contraindication of fibrate medications?

Answer 6

Do not take while on anticoagulants

Question 7

What are the main nicotinic acid medications

Answer 7

niacin

vitamin b2

Question 8

What is the reason nicotinic acids are not well tolerated?

Answer 8

they require large doses. Only 20% of patients can handle them

Question 9

What is the main cholesterol absorption inhibitor?

Answer 9

ezetimibe

Question 10

All HMG-CoA medications end in what suffix?

Answer 10

-statin

Question 11

What are the 5 main statin medications?

Answer 11

• fluvastatin
• pravastatin
• rosuvastatin
• simvastatin
• vatorstatin

Question 12

What are the two main lab tests while taking statins?

Answer 12

Homocysteine and High sensitivity C-reactive protein

Question 13

What are the normal levels for homocysteine?

Answer 13

4-17 mmol/L fasting

Question 14

What is the reference value for hsCRP?

Answer 14

less than 0.175 mg/ml

• low risk less than 1mg/L
• Mod risk 1-3mg/L
• High risk greater than 3mg/L

Question 15

What does hsCRP detect?

Answer 15

inflammatory process d/t buildup of atherosclerotic plaque in the arterial system. Especially coronary arteries