Week 2 - Exam 1 Flashcards
1
Q
posology
A
the study of drug doses
2
Q
minimal therapeutic dose
A
smallest dose that creates a therapeutic effect
3
Q
maximum therapeutic dose
A
largest dose that creates a therapeutic effect without toxicity
4
Q
ED50
A
effective dose 50, dose that causes therapeutic effect in 50% animals
5
Q
ED99
A
effective dose 99, dose that causes therapeutic effect in 99% animals
6
Q
toxic dose
A
produces adverse clinical, hematological, or biochemical changes
7
Q
lethal dose
A
dose that causes death
8
Q
LD50
A
causes death in 50% animals
9
Q
LD1
A
causes death in 1% animals
10
Q
therapeutic index (TILE)
A
ratio between the The LD50/ED50
11
Q
SSM
A
standard safety margin
12
Q
SSM 100%=
A
(LD1-ED99/ED99) x 100
13
Q
Certain safety factor
A
ratio between LD1/ED99
14
Q
100 mg/ml in percent and ratio
A
10%, 1:10
15
Q
10 mg/ml in percent and ratio
A
1%, 1:100
