Ionization of Drugs - Exam 3

Question 1

membranes are more permeable to

Answer 1

non-ionized forms of drugs (lipid soluble, no electric charge)

Question 2

ionization depends on

Answer 2

weak acid or weak base, pKa of drug, pH of medium on either side of the membrane

Question 3

pKa =

Answer 3

pH of drug where 50% ionized & 50% non-ionized

Question 4

passive diffusion with pKa, weak acid will be

Answer 4

high “high on acid”, curve starts at low % ionization, then with increasing pH goes high

Question 5

passive diffusion with pKa, weak base will be

Answer 5

low “drop that base”, curve starts at high % ionization, then with increasing pH goes low

Question 6

Henderson Hasselbach Equation used to

Answer 6

determine degree of ionization of the drug based on the pH of the environment

Question 7

pKa of acid =

Answer 7

pH of medium + log N/I

Question 8

pKa of base =

Answer 8

pH of medium + log I/N

Question 9

if a drug is basic give it

Answer 9

injectable

Question 10

if a drug is acidic give it

Answer 10

oral

Question 11

antilog 1

Answer 11

10

Question 12

antilog 2

Answer 12

100

Question 13

antilog 3

Answer 13

1000

Question 14

antilog -1

Answer 14

0.1

Question 15

antilog -2

Answer 15

0.01

Question 16

antilog -3

Answer 16

0.001

Question 17

if pH = pKa then…

Answer 17

50% ionized & 50% nonionized

Question 18

quarternary nitrogen compounds

Answer 18

mostly ionized so majority of it is excreted without being absorbed by the body; i.e.: Tubocurarine

Question 19

weak acids are more ionized in what medium

Answer 19

alkaline

Question 20

weak bases are more ionized in what medium

Answer 20

acidic

Question 21

acids are more absorbed in what environments

Answer 21

acidic

Question 22

bases are more absorbed in what environments

Answer 22

basic

Question 23

what drug is basic (enhance excretion of acids)

Answer 23

sodium bicarbonate or anything ending in -ine

Question 24

what drug is acidic (enhance excretion of bases)

Answer 24

ammonium chloride or methionine