Week 11- Unit 3 Flashcards
The emulsified micelles containing, bile acids, monoglycerols, free fatty acids and cholesterol interact with the intestinal wall and are trasported in the blood in _______.
Cholymicrons
Cholymicrons function to transports DIETARY ______ and ____ to the peripheral tissues.
lipids
cholesterol
_____ and ______ are associated with cholymicrons and are integral for the functionality of these lipoproteins.
ApoB48
ApoCII
After the lingual and gastric lipases digest the dietary triacylglycerols, _______ will emulsify the triglycerols, then ____ and ____ will break down the Triglycerols in the small intestine.
Bile salts
Pancreatic lipase
Colipase
What does the action of pancreatic lipase and colipase do to the TG?
Breaks the TG into Free fatty acids and Monoacylglycerols (2-MG) in the small intestine
What does the Micelle form do ?
facilitate the movement of FA and Monoacyglycerols into the intestinal epithelium
What composes a Triglyceride?
Glycerol unit (3-C chain with hydrogens) 3 Fatty Acid Chains (Hydrocarbon chain)
Bile salts are _______ compounds synthesized in the liver from _______. They act as detergents and bind to the fat.
Amphipathic (both hydrophilic and phobic properties)
Cholesterol
Bile salts act as detergents that increase the _____ _____ of the Fats so that they are broken down easier during peristalsis action.
surface area
Where is Pancreatic lipase and Colipase made?
Secreted from pancreas
Pancreatic lipase and Colipase is secreted from the pancrease in response to the hormone _______.
Cholecystokinin
At the same time Cholecystokinin is signaling to the pancreas , ______ (hormone) signals the release of ________.
Secretin
Bicarbonate
What does the release of Bicarbonate into the intestine by Secretin do ?
increases intestinal pH to about 6 - more amenable to enzyme activity
Initially , coating of bile salts ______ pancreatic lipase.
inhibits
Colipase will bind to dietary fats and ______ the inhibition that the coating of bile salts causes on the action of pancreatic lipase.
relieve
Once Colipase binds to dietary fats and the inhibition on pancreatic lipase is relieved, the Pancreatic lipase will digest dietary fats through _______.
Hydrolysis (into FA+Monoglycerol)
What is the product of digestion of a trigyceride by Pancreatic lipase and Colipase?
2 Free Fatty Acids
2-Monoacyglycerol
Micelles are packages that will contain what 4 things?
Cholesterol
Phospholipids
FFA
Monoacylglycerides
Micelles are again emulsified by ______ _____.
Bile salts
More than ___ of Bile salts are reabsorbed. They travel through the ______ circulation and return to the liver and redeposited in the gall bladder.
95%
Enterohepatic
The micelle will interact with the ___ ____ villae. They can then diffuse into the intracellular space of the intestinal epithelial cells.
Brush Border
After diffusion of lipid molecules enter the intestinal epithelial cells, where do they go first and what happens?
Smoooth ER
-FFA are repackaged into Triglycerides for transport in Cholymicrons
In the Smooth ER of the intestinal cell, the FFA is combined with ATP to make FA-AMP and then interacts with what to make what product?
interacts with CoAsh
Product is FA-CoA
and AMP is release in creation of product
What is the purpose of the FA-CoA?
It will create a condensation reaction acting on the 2-Monoacylglycerol (releasing CoAsh used as energy) to make:
Diacylglycerol