Unit 3 Weekly Quiz reviews

Question 1

Under fasting conditions, acetyl CoA carboxylase will be inhibited by an increase in what compound?

Answer 1

Palmitoyl coA

Question 2

During FA synthesis, after the initial step involving acetyl CoA, the FA chain is elongated by the addition of what compound?

Answer 2

Malonyl CoA

Question 3

THe process of keotgenesis refers to the conversion of acetyl CoA to what two compounds ?

Answer 3

Beta hydroxybutyrate

Acetoacetate

Question 4

What protein is responsible for the transfer of ApoB48 to nascent chylomicrons before secretion into blood?

Answer 4

Microsomal transfer protein (MTP)

Question 5

The transport of newly synthesized FA to the adipose requires Carnitine to shuttle the FA out of the mitochondria. True or False?

Answer 5

False

Question 6

What is the primary component of VLDL?

Answer 6

Triacylglycerols

Question 7

Shortly after a meal high in fat, you would expect an elevation of what lipoprotein in circulation?

Answer 7

Chylomicrons

Question 8

During the fasted stat, lipolysis is facilitated by the action of hormone sensitive lipase. this enzyme requires what post-translational modification for activation?

Answer 8

Phosphorylation

Question 9

What is the regluated step of FA synthesis in Eukaryotes?

Answer 9

Carboxylation of Acetyl coA

Question 10

LCAT esterifies cholesterol. This process is required for what process?

Answer 10

To trap cholesterol in HDL particles

Question 11

Secondary bile salts are generated by bacterial modification of primary bile salts in the intestinal lumen. What will these modifications do to the solubillity of bile salts?

Answer 11

Decrease solubility

Question 12

What is the regulatory enzyme for cholesterol synthesis ?

Answer 12

HMG-CoA reductase

Question 13

A deficiency in the LDL receptor will result in what ?

Answer 13

Decrease in intracellular cholesterol

Question 14

Under cellular conditions, when cholesterol is low, what will the Sterol response element binding protein (SREBP) be doing?

Answer 14

It will be associated with the sterol response element (SRE) in the DNA (for making more endogenous cholesterol)

Question 15

The uptake of LDL increases intracellular cholesterol levels. This will ______ degradation of HMG-CoA reductase.

Answer 15

increase

Question 16

What lipoprotein is responsible for the transport of peripheral tissues?

Answer 16

LDL

Question 17

HDL particles are characterized by the presence of which apoprotein ?

Answer 17

ApoA

Question 18

Under fasting conditions, glucagon is elevated, what enzyme will be phosphorylated and inactive?

Answer 18

HMG-CoA-reductase

Question 19

HDL particles and VLDL particles exchange cholesterol ester for TG. What enzyme is responsible for this?

Answer 19

Cholesterol Ester transfer protein (CETP)

Question 20

What term is used to describe macrophages filled with oxLDL?

Answer 20

Foam cells

Question 21

What do Statin drugs inhibit to inhibit cholesterol synthesis ?

Answer 21

HMG-CoA reductase

Question 22

HMG CoA reductase will _______ the first commited step in ______ biosynthesis .

Answer 22

catalyze

cholesterol

Question 23

What lipoprotein is responsible for transport of FA synthesized de novo in the liver?

Answer 23

VLDL

Question 24

The two major processes to maintain blood glucose are

Answer 24

GNG

Hepatic Glycogenolysis

Question 25

What is the regulated step of FA synthesis in eukaryotes?

Answer 25

Carboxylation of acetyl CoA

Question 26

Under fasted conditions, (glucagon is elevated), what enzyme will be phosphorylated and inactivated in cholesterol synthesis?

Answer 26

HMGCoA reductase

Question 27

Adiponectin is secreted from adipocytes. One of the primary roles of adiponectin is to activate the MAPK pathway in skeletal muscle which enhances the activity of what pathway?

Answer 27

Beta Oxidation

Question 28

What hormone initiates skeletal muscle catabolism to priovide substrate for GNG?

Answer 28

Cortisol (stimulated release)

Question 29

True or false:

Under conditions of starvation, AMP kinase will be active.

Answer 29

True

Question 30

True or False:

Under conditions of starvation, Malonyl CoA will be elevated.

Answer 30

False