Unit 4 and Course Review Flashcards
What enzyme is regulated by N-Acetyl Glutamate (NAGs)?
CPS 1
What AA is considered non-essential because it is generated by the Urea cycle?
Arginine
The reaction of freee ammonia with alpha-ketoglutarate is catalyzed by _____ and requires _____ as a reactant.
Glutamate Dehydrogenase (GDH)
NADH or NADPH
Transamination of all AA requires what cofactor?
PLP (Pyridoxal Phosphate)
What enzyme will be the first initiator that activates all the pancreatic zymogens required for protein digestion?
Enteropeptidase
Pepsinogen is activated by what mechanism(s)?
Change in pH (high Acidity HCL in stomach)
or
Autocleavage
When is the process of autophage most likely occurring within the cell?
When there is low energy in the cell: ratio of AMP/ATP is greater than 1
mTOR pathway is related to the process of autophagy. When mTOR is active, this is most consistent with what in regards to autophagy?
Autophagy is inhibited
A deficiency in which of the following enzymes will not result in an increase in orotic acid?
- Arginosuccinate lyase
- Arginosuccinate synthetase
- N-Acetylglutamate
- Ornithine transcarbamolayse
- N-Acetylglutamate (will only effect lack of Carbamoyl phosphate synthesis due to lower output from CPS 1)
Which of the following will contribute to elevated Triglycerides in individuals with Type 2 Diabetes?
- Increased Glycolysis
- Decreased Beta-oxidation
- Reduced activity of LPL
- Increased activity of PPP
- Reduced activity of Lipoprotein lipase
- if insulin sensitivity is lacking, LPL activity will be reduced, this will result in a decrease in TG storage and increase in circulation levels
Alanine can be shuttled from the skeletal muscle to the liver where it is deaminated by what enzyme ?
Alanine aminotransferase
The primary role of glutamine in the brain is to provide substrate for the synthesis of which following compounds?
- Glutamate
- Neurotransmitters
- BCAAs
- Urea
- Neurotransmitters
During exercise, the pathways of ______ and ______ are integrated as means of providing energy and reducing NH4+ levels.
BCAA catabolism and Purine Degradation
Which GLUT transporter facilitates glucose uptake in skeletal muscle?
GLUT 4
In the case of an individual in a sedentary lifestyle eating a diet consisting of 50%carbs, 30% protein, 20% fat, this individual would be in ________ nitrogen balance.
Neutral
Glutamine is metabolized to bicarbonate ion in the ______ to replenish this important component of the blood buffering system.
Kidneys
True or False:
The Pool of AA is strictly controlled, similar to blood glucose.
False
Under fasting conditions what will the liver transition to the use of for energy?
Fatty acids (not ketones)
True or False:
GNG and Beta Oxidation are coupled. Beta oxidation helps facilitate GNG by providing Acetyl CoA as substrate for GNG
False- They are coupled but Actetyl CoA can not be a substrate for GNG
-it is only for allosteric activation of Pyruvate Carboxylase required for GNG (makes Pyruvate into OAA)
What can a deficiency in pyruvate carboxylase do ?
prevents GNG from occurring as Pyruvate is not coverted to OAA
- instead excess goes to make excess lactate
Release of ACTH , from the pituitary, can be inhibited by which hormone?
Cortisol (from adrenal cortex)
What two things can inhibit the release of GH from the anterior pituitary?
Somatostatin
IGF-1
When cortisol is elevated, _____ _______ synthesis is enhanced.
Hepatic protein
protein translation
Exams can be stressful and elicit release of Cortisol. This will help the body maintain supply to your brain of glucose by decreasing ____ _____ in the skeletal muscle.
glucose uptake