Week 1 Random Flashcards
Bloom’s Taxonomy
Components of Diagnosis
Explanation
Prognostication
Therapy
H & P
HISTORY
Chief Complain History of present illness Past medical history Surgical history Family history Social history Sexual history Review of systems Allergies Medications
PHYSICAL
Physical exam Labs Imaging and other ancillary tests Assessment/Differential Diagnosis
AP & CP and subcategories
AP
Surgical Pathology, Cytology, Hematopathology, Autopsy
CP
Clinical Chemistry, Microbiology, Blood Bank/Transfusion/ Molecular and Genetic Pathology, Hematopathology
Why order tests
Routine
Preoperative
Monitoring
Diagnostic
Lab categories
Chemistry
Urinalysis
Microbiology
Hematology
Serology (antigen interaction)
Reference Range vs. Optimal Range
Reference range – “normal” that encompasses 95% of population; specific to the equipment
Optimal (health) range – therapeutic target associated with optimal health set by us
Analytic Variability vs. Intraindividual variability
Analytic Variability – variability due to equipment
Intraindividual variability – natural biological fluctuations
General Chemistry (lab) / CMP
Aka Chem20, Profile1, Chem7 Comprehensive Metabolic Panel (CMP)
Liver, kideny, electrolytes, lipids, and glucose test
Liver function
- Synthesis and secretion of proteins Storage of energy (glycogen)
2 Metabolizes many drugs and toxins
- Transformation and Clearance (e.g. conjugation of bilirubin)
- Aids digestion (biliary system)
AST/ALT elevation
Hepatic injury or necrosis:
- viral hepatitis
- fatty liver
- toxins (including medications)
- strenuous exercise
What is the cause for uncojugated and conjugated bilirubin elevation?
Unconjugated: ELEVATED
- hemolysis
- kernicterus (destuction of baby’s blood)
- Crigler-Najjar syndrome (deficiency of conjugating enzyme)
- Gilbert’s disease (reduced activity of glucuronyltransferase)
Conjugated: ELEVATED
(due to obstruction)
- hepatitis,
- dubin-johnson syndrom (obstruction in secretion of conjugated form into bile)
- biliary obsturction (bile cannot flow into intestine)
Hemoglobim breakdown
Hemoglobim
heam
biliverdin
bilirubin (uncoj)
bilirubin (conj)
urobilinogen
stercobiliongen
Albumin function
- Main agent of intravascular osmotic pressure
- Serves in the transport of bilirubin, hormones, and metals, vitamins, and drugs
* making 150-250mg/kg/day
Albumin increas and decrease
INCREASE:
- Dehydration Decrease:
DECREASE (synthesis):
- End-stage liver disease
- intestinal malabsorption syndromes
- protein malnutrition e.g.
DECREASE (loss):
- nephrotic syndrome
Globulin function composition and test for the level
COMPOSITION
Serum proteins including carrier proteins
Enzymes
Complement
TEST
immunoglobulins serum electrophoresis
Kideny function
Filters 200L & removes 2L
Produces Erythropoeitin
Produces Renin
Produces Vit D
Kidney tests
- Blood Urea Nitrogen (BUN) – measures breakdown of proteins
- Creatinine – breakdown product of creatine in muscles
- Urinalysis (physical, chemical e.g. glucose, bilirubin, protein, leukocyte, pH, specific gravity, and microscopic examination)
Blood in urine symptom
Urinary Bladder Cancer
Heart tests
- Lipid Panel (possible blockage - artheroschlerosis)
- Beta Natriuretic Protein (released when heart stretches)
- Troponins (damage to muscle)
Brain tests
Lumbar puncture: protein, glucose, cell differential, culture, blood
Lungs tests
Arterial Blood Gas (ABG) pH, O2, CO2
Endocrine tests
Hemoglobin
A1c
TSH
FSH
LH
PTH
Testosterone
Estrogen *
Osler’s Rule
Correlate all abnormalities into a single plausible explanation
Differential diagnosis
A systematic diagnostic method used to identify the presence of an entity where multiple alternatives are possible. Systematically obtain information then use process of elimination
Progressive disclosure
interaction design technique often used in human computer interaction to help maintain the focus of a user’s attention by reducing clutter, confusion, and cognitive workload. This improves usability by presenting only the minimum data required for the task at hand.
RCT
Randomized Control Trial
Prodivdes fair conclusion and blinding
Removes bias
Coincidence vs. Concoted incidence
Coincidence – unlikely event occurring by chance
Bayes’ Theorem
Allows calculation of a probability if something is correct or incorrect based on the evidence
Research questions should be…
Types of research questions…
Qualities:
Specific, answerable, novel, and relevant
Types:
descriptive, evaluative, and explanatory
Evidence Based Medicine practice requirement:
AAAAA
Asses the patient (clinicla problem)
Ask the clinical question (PICO)
Acquire the evidence (search for evidence)
Appraise the evidence (usability and closeness to truth)
Apply
Types of studies
Case series and case reports (based on chart notes)
Case control studies (base on chart notes with control notes)
Cohort studies (follow the group)
Randomized Control Studies
Declaration of Helsinki
The placebo can be only used when no alternative drugs are availible.
Patient consent.
Bradford-Hill Criteria for Causation
- Strength of association
- Consistency of different studies
- Specificity of association with particular disease
- Temoral relationship (exposure precedes disease)
- Biological gradient (dose-response relationship)
- Plausability (biological plausilibity)
- Coherence (consistent with what is known)
- Experiment reversibility
- Existence of analogous evidence
Types of imaging
X-Ray Fluoroscopy (X-Ray real time)
CT scan (forms sections)
MRI (joints, neural tissue, dense breast tissue no good for blood or bone)
Ultrasound (sonar, water)
Mammography (good for dense breast tissue, not good for masses of blood, better for soft tissue)
Sievert values
1 Sv 5.5% chance of cancer
10,000 mSv radiation sickness
50 mSv lowest dose for cancer
15 mSv C.T. Scan of abdomen and pelvis
2 mSv head C.T. Scan
2 mSv natural radiation/year
- 10 mSv cheast X-ray
- 01 mSv dental X-ray
Standard position for Chest X-ray
PA
Number of X-Rays required to visualize 3D
2
X-Ray depends on
Atomic number, density, and thickness
Types of X-Ray anodes
Usually – tungsten
Mammography – rhodium
Types of contrast media
High Osmolar HOCM
Low Osmolar LOCM
Iso Osmolar IOCM
Air-Liquid interfaces
Help to determine the position
Relationship between penetration, contrast, and voltage
Up penetration -> lower contrast
Up penetration -> higher voltage
Body penetration reduces dose Object
Penetration reduces contrast
Window setting
Allow adjustment and focus on a specific tissue
Contrasts medium
Barium (Ba) CT – safe unless there is a perforation
Gadolinium (Ga) MRI – changes the relaxation time; dangerous to kidney function if reduced; may cause nephrogenic systemic fibrosis (NSF)
Senescent
No division
Prescription abbreviations ac ; bid ; gtt ; od/s ; po ; pc ; prn ; q4h ; qd ; tid ; IV ; IM
ac - antre cibum - before meals
bid - bis in die - twice a day
gtt - gutta - drops
od - oculus dexter - right eye
os - oculus sinister po -
per os - by mouth
pc - post cibum - after meals
prn - Pro re nata - as needed
q3h - quaque 3 hora - every 3 hours
qd - quaque die - every day
tid - ter in die - 3 times a day IV (intravenously)
Prescription components
SUPERSCRIPTION
1) Name of practitioner including address
2) Patients name, address, age, weight, and date
INSCIRPTION
3) Drug name, strength, quantity, ect.
SUBSCRIPTION
4) Directions
5) Refil times
6) Label
7) Specify if brand and not generic is desired
8) Signature of practitioner
Categories of drugs
Over-the-Counter
Legend Drugs (prescription)
Controlled Substances (Principal or secondary site of action is the Central Nervous System generally)
Classification of controlled substances
Schedule I: no currently accepted medical use and may lead to serious dependence
Schedule II: accepted medical use; may lead to severe dependence; may not be refilled; must be filled within 14 days (nv); do note fill before/dispense until; handwrited only; separate sheet
Schedule III: Moderate to low physical dependence and possible high psychological dependence; 6 refill
Schedule IV: Low dependence; 6 refill
Schedule V: Limited dependence liability
Requirements for prescribing controlled substances
DEA number
Registered with specific state
Visible proof of registration
Legitimate medical purpose
Cannot self-prescribe Schedule II-IV
Bio-equivalents Therapeutic Equivalents
Bio-equivalents – the same chemical property of a generic drug
Therapeutic Equivalents – the same effect of the drug
FDA Recall drugs classes
Class I – Severe health consequence
Class II – cause temporary or medically reversible adverse health
Class III – is not likely to cause adverse health
FDA Category Use in Pregnancy
Category A – fail to demonstrate a risk to the fetus
Category B
Category C – Drugs should be given only if the potential benefit justifies the potential risk to the fetus
Category D – There is positive evidence of human fetal risk
Category X – the risk of the use of the drug in pregnant women clearly outweighs any possible benefit
Human mitochondrial genome
16.5 kb mtDNA encodes
13 proteins 22 tRNAs, and 2 rRNAs