Week 1-L3 pharmacology

Question 1

pharmacology definition

Answer 1

chemical substance, interacts with specific target within biological system to produce physiological effect

Question 2

3 questions of pharmacology

Answer 2

where is the effect produced, which target for drug and what effect does it produce

Question 3

E.g heroin where, target and response

Answer 3

effect of euphoria, target opioid receptors and at peri-aquaductal grey region, ventral segmental are and solitary nucleus

Question 4

drug target types

Answer 4

receptors, enzymes, transport proteins and ion channel

Question 5

atorvastatin

Answer 5

enzyme

Question 6

amlodipine

Answer 6

ion channel

Question 7

salbutamol

Answer 7

receptor

Question 8

citalopram

Answer 8

transport proteins

Question 9

effects of drugs on target

Answer 9

stimulatory or inhibitory effects

Question 10

drug selectivity

Answer 10

need high degree of selectivity though the lock and key hypothesis to a particular target

Question 11

why is selectivity more important in drugs than endogenous compound

Answer 11

endogenous compound are released at the site of target receptors while the drugs circulate around the whole body

Question 12

sides effects definition

Answer 12

effect produced by the drug that is secondary to the intended effect

Question 13

reasons for side effects

Answer 13

off target-effects on the same target at wrong place
or effect on other target in the same or other tissue
or dose dependent

Question 14

safest drug

Answer 14

large difference between the dose required to induce desired effect and the dose required to induce side effects