Week 1 Cellular Responses to Injury- Krafts

Question 1

What are where are ependymal cells?

Answer 1

• line ventricles
• have cilia for movement of CSF
• Microvilli for absorption
• Make CSF
• Make up choroid plexus

Question 2

Oligodendrocytes

Answer 2

• produce myelin
• darker chromatin than astrocytes
• small than astrocytes

Question 3

RED NEURONS

Answer 3

• Acute injuries (like infarction)
• appears brighter pink
• LOSS OF BLOOD FLOW (stroke)
• represent dying neurons

Question 4

COWDRY Bodies

Answer 4

-Associated with Herpesvirus

Question 5

NEGRI Bodies

Answer 5

-Associated with rabies virus

Question 6

Neurofibrillary Tangles

Answer 6

• Associated with degenerative diseases like Alzheimer’s disease
• Fibers are accumulation of amyloid
• Fibers will eventually kill the neuron

Question 7

Lewy Body

Answer 7

Associated with parkinson’s

Question 8

Function of Astrocytes

Answer 8

• React to injury and establish/ maintain the blood brain barriers
• Wrap around blood vessels to help BBB
• Can provide glycogen or lactate for cells
• Can proliferate

Question 9

What is Gliosis?

Answer 9

Proliferation of astrocytes

Question 10

Gemistocytic astrocyte

Answer 10

Increase in size as a result of injury and increase in number of astrocyte

Question 11

Cytoplasmic swelling of astrocytes

Answer 11

In response to lack of oxygen
Toxin
Or damage to pumps in cell membrane

Question 12

Rosenthal Fibers

Answer 12

Markers for injury
made of protein
seen in many disease so not very specific

Question 13

Corpora amylacea

Answer 13

peral like
lamellated
collections of glycoaminoglycna
Part of NORMAL aging process
NOT pathologcial

Question 14

Microglia

Answer 14

Phagocytose intruders

-forms nodules around dead cells