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Step 1 Immunology > WBC Neoplasms > Flashcards

WBC Neoplasms Flashcards

1
Q

Auer rods

A

AML, esp. APL

MPO crystal aggregates

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2
Q

t(9:22)

A

BCR/ABL

CML, ALL

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3
Q

Mutation in CML

A

t(9:22) - BCR/ABL

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4
Q

Mutations in B-ALL

A

t(9:22) - BCR/ABL; adults

t(12:21); kids

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5
Q

t(14:18)

A

BCL2

Follicular lymphoma

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6
Q

Mutation in Follicular Lymphoma

A

t(14:18) - BCL2

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7
Q

t(11:14)

A

Cyclin D2

Mantle cell lymphoma

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8
Q

Mutation in mantle cell lymphoma

A

t(11:14) - Cyclin D2

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9
Q

t(8:14)

A

C-MYC

Burkitt Lymphoma

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10
Q

Mutation in Burkitt Lymphoma

A

t(8:14) - C-MYC

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11
Q

JAK2

A

Myelofibrosis, PV, ET

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12
Q

Mutation in PV

A

JAK2

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13
Q

Mutation in myelofibrosis

A

JAK2

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14
Q

Mutation in ET

A

JAK2

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15
Q

Mutation in APL

A

t(15:17) - RAR

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16
Q

t(15:17)

A

RAR

APL

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17
Q

Tx in CML

A

imatinib (BCR/ABL inhibitor)

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18
Q

Tx considerations in B-ALL

A

prophylax @ scrotum and CNS

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19
Q

Tx in Hairy Cell Leukemia

A

Cladribine, pentostatin

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20
Q

Tx in Follicular Lymphoma

A

rituximab (Anti-CD20 Ab)

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21
Q

Tx in APL

A

ATRA

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22
Q

Tx in PV

A

Aspirin, hydroxyurea

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23
Q

Basophilia with (-) LAP stain

A

CML

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24
Q

Increasing splenomegaly in CML implies

A

transformation to acute leukemia

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25
Q

Pruritis after showering, flushing, erythromyalgia

A

PV

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26
Q

Complications in PV

A

Gout

Thrombosis @ hepatic vein, portal vein, dural sinus

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27
Q

Auer rods

A

MPO aggregates in AML

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28
Q

APL presents with

A

DIC

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29
Q

Gum infiltration

A

Monocytic AML

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30
Q

Down Syndrome,

A

Megakaryoblastic AML

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31
Q

Tear-drop RBCs

A

Myelofibrosis

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32
Q

Etiology of marrow fibrosis in myelofibrosis

A

PDGF

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33
Q

Complications in Essential Throbocythemia

A

Bleeding, thrombosis, erythromyalgia

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34
Q

MPD with no risk of gout, fibrosis, or leukemia

A

Essential throbocythemia

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35
Q

SVC syndrome in teens

A

T-ALL

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36
Q

TdT+, CD2-8+

A

T-ALL

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37
Q

TdT+, CD10, CD19, CD20

A

B-ALL

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38
Q

1 Adult Leukemia

A

CLL

39
Q

1 NHL

A

DLBCL

40
Q

CD20+, CD5+

A

CLL

41
Q

Immunoglobulins in CLL

A

Decreased (increased risk of infx)

42
Q

Complications of CLL

A

Autoimmune hemolytic anemia, infection

43
Q

LAD in CLL

A

Small Lymphocytic Leukemia

44
Q

CLL at risk of transformation to

A

DLBCL (Richter transformation)

45
Q

+TRAP

A

Hairy Cell Leukemia

46
Q

Exam findings in Hairy Cell Leukemia

A

SM, dry tap

47
Q

Hypertrophic in Hairy Cell Leukemia

A

Red pulp of spleen

48
Q

Painless “waxing and waning” LAD

A

Follicular Lymphoma

49
Q

Follicular lymphoma at risk of transformation to

A

DLBCL

50
Q

Small cell NHL

A

FL, MCL, MZL

51
Q

Population at risk of Mantle cell lymphoma

A

Males, late adulthood

52
Q

Population at risk of Marginal Zone Lymphoma

A

Chronic inflammation, esp. Sjogren, Hashimodo, and H. Pylori

53
Q

Cancer associated with H. pylori

A

MALToma

54
Q

Intermediate cell lymphoma

A

Burkitt Lymphoma

55
Q

Pathogen associated with Burkitt Lymphoma

A

EBV

56
Q

Pathogen associated with MALToma

A

H. Pylori

57
Q

Population at risk for Burkitt lymphoma

A

Adolescents and young adults
African endemic areas
HIV/AIDS

58
Q

Presentation in African endemic and sporadic Burkitt’s

A

African endemic: Jaw

sporadic: Pelvis and abd

59
Q

“Starry sky”

A

Burkitt Lymphoma

60
Q

Diffuse sheets

A

DLBCL

61
Q

Population at risk for DLBCL

A

Bimodal: kids, older adults

62
Q

Most aggressive NHL?

A

DLBCL

63
Q

Rash, lytic bone lesions, hypercalcemia

A

ATLL

64
Q

Cells in ATLL

A

CD4+

65
Q

Populations at risk for ATLL

A

IV Drug users

Japan, Caribbean, W Africa

66
Q

Similarities in ATLL and multiple myeloma

A

Lytic “punched out” bone lesions, hypercelcemia

67
Q

Rash, plaques, nodules

A

Mycosis fungoides

68
Q

Ceribriform cells

A

Sezary cells - mycosis fungoides

69
Q

Abscesses in mycosis fungoides are called

A

Pautrier microabscesses

70
Q

Cells in mycosis fungoides

A

CD4+

71
Q

Sezary syndrome

A

Mycosis fungoides with blood involvement

72
Q

Fried egg/clock face cells

A

multiple myeloma

73
Q

Cytokine increased in Multiple Myeloma

A

IL-6

74
Q

Ig increased in Multiple Myeloma

A

IgG or IgA

75
Q

Smear findings in multiple myeloma

A

Roleaux

76
Q

Complications of multiple myeloma

A

Hypercalcemia, Renal failure, Amyloidosis, Anemia, lytic bone lesions (CRAAB)

77
Q

Overproduced in multiple myeloma, and related findings

A

Ig light chains: proteinuria, amyloidosis, proteinuria, proteinemia

78
Q

Cause of hypercalcemia in multiple myeloma

A

increased OAF, activating osteoclast RANK receptor

79
Q

Increased IgM

A

Waldenstrom macroglobulinemia

80
Q

Complications in Waldenstrom macroglobulinemia

A

Hyperviscosity: vision and neuro Sxs, bleeding

81
Q

Condition that can progress to multiple myeloma

A

MGUS

82
Q

CD15, CD30+

A

RS cells in Hodgkin lymphoma

83
Q

Better prognosis in HL predicted by

A

increased lymphocytes in mass

84
Q

Young woman presents with enlarging cervical LN

A

Nodular sclerosing type HL

85
Q

HL with eosinophilia; type and cause

A

Mixed cellularity; IL-5

86
Q

Nodular sclerosing type HL: histology

A

Bands of sclerosis divide node into nodules; lacunar cells

87
Q

Birbeck granules

A

“Tennis racket” shaped granules in langerhans cell histiocytosis

88
Q

Skin involvement in langerhans cell histiocytosis is associated with

A

malignancy

89
Q

Teen presents with pathological fracture; disorder and histological findings?

A

Eosinophilic granuloma; lots of eosinophils

90
Q

Langerhans cell histiocytosis with scalp involvement; disorder and at-risk population

A

Hand-Schuller-Christian Disease; >3y/o

91
Q

Leukemia in Downs Syndrome >5y/o

A

ALL

92
Q

Hand-Schuller-Christian Disease: site of bone involvement

A

skull

93
Q

rash with cystic bone defects; disorder, at risk population, prognosis

A

Letterer-Siwe disease;

94
Q

S100+, CD1a+

A

Langerhans cells

Step 1 Immunology (13 decks)

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