WBC Neoplasms Flashcards
1
Q
Auer rods
A
AML, esp. APL
MPO crystal aggregates
2
Q
t(9:22)
A
BCR/ABL
CML, ALL
3
Q
Mutation in CML
A
t(9:22) - BCR/ABL
4
Q
Mutations in B-ALL
A
t(9:22) - BCR/ABL; adults
t(12:21); kids
5
Q
t(14:18)
A
BCL2
Follicular lymphoma
6
Q
Mutation in Follicular Lymphoma
A
t(14:18) - BCL2
7
Q
t(11:14)
A
Cyclin D2
Mantle cell lymphoma
8
Q
Mutation in mantle cell lymphoma
A
t(11:14) - Cyclin D2
9
Q
t(8:14)
A
C-MYC
Burkitt Lymphoma
10
Q
Mutation in Burkitt Lymphoma
A
t(8:14) - C-MYC
11
Q
JAK2
A
Myelofibrosis, PV, ET
12
Q
Mutation in PV
A
JAK2
13
Q
Mutation in myelofibrosis
A
JAK2
14
Q
Mutation in ET
A
JAK2
15
Q
Mutation in APL
A
t(15:17) - RAR
16
Q
t(15:17)
A
RAR
APL
17
Q
Tx in CML
A
imatinib (BCR/ABL inhibitor)
18
Q
Tx considerations in B-ALL
A
prophylax @ scrotum and CNS
19
Q
Tx in Hairy Cell Leukemia
A
Cladribine, pentostatin
20
Q
Tx in Follicular Lymphoma
A
rituximab (Anti-CD20 Ab)
21
Q
Tx in APL
A
ATRA
22
Q
Tx in PV
A
Aspirin, hydroxyurea
23
Q
Basophilia with (-) LAP stain
A
CML
24
Q
Increasing splenomegaly in CML implies
A
transformation to acute leukemia
25
Pruritis after showering, flushing, erythromyalgia
PV
26
Complications in PV
Gout
| Thrombosis @ hepatic vein, portal vein, dural sinus
27
Auer rods
MPO aggregates in AML
28
APL presents with
DIC
29
Gum infiltration
Monocytic AML
30
Down Syndrome,
Megakaryoblastic AML
31
Tear-drop RBCs
Myelofibrosis
32
Etiology of marrow fibrosis in myelofibrosis
PDGF
33
Complications in Essential Throbocythemia
Bleeding, thrombosis, erythromyalgia
34
MPD with no risk of gout, fibrosis, or leukemia
Essential throbocythemia
35
SVC syndrome in teens
T-ALL
36
TdT+, CD2-8+
T-ALL
37
TdT+, CD10, CD19, CD20
B-ALL
38
#1 Adult Leukemia
CLL
39
#1 NHL
DLBCL
40
CD20+, CD5+
CLL
41
Immunoglobulins in CLL
Decreased (increased risk of infx)
42
Complications of CLL
Autoimmune hemolytic anemia, infection
43
LAD in CLL
Small Lymphocytic Leukemia
44
CLL at risk of transformation to
DLBCL (Richter transformation)
45
+TRAP
Hairy Cell Leukemia
46
Exam findings in Hairy Cell Leukemia
SM, dry tap
47
Hypertrophic in Hairy Cell Leukemia
Red pulp of spleen
48
Painless "waxing and waning" LAD
Follicular Lymphoma
49
Follicular lymphoma at risk of transformation to
DLBCL
50
Small cell NHL
FL, MCL, MZL
51
Population at risk of Mantle cell lymphoma
Males, late adulthood
52
Population at risk of Marginal Zone Lymphoma
Chronic inflammation, esp. Sjogren, Hashimodo, and H. Pylori
53
Cancer associated with H. pylori
MALToma
54
Intermediate cell lymphoma
Burkitt Lymphoma
55
Pathogen associated with Burkitt Lymphoma
EBV
56
Pathogen associated with MALToma
H. Pylori
57
Population at risk for Burkitt lymphoma
Adolescents and young adults
African endemic areas
HIV/AIDS
58
Presentation in African endemic and sporadic Burkitt's
African endemic: Jaw
| sporadic: Pelvis and abd
59
"Starry sky"
Burkitt Lymphoma
60
Diffuse sheets
DLBCL
61
Population at risk for DLBCL
Bimodal: kids, older adults
62
Most aggressive NHL?
DLBCL
63
Rash, lytic bone lesions, hypercalcemia
ATLL
64
Cells in ATLL
CD4+
65
Populations at risk for ATLL
IV Drug users
| Japan, Caribbean, W Africa
66
Similarities in ATLL and multiple myeloma
Lytic "punched out" bone lesions, hypercelcemia
67
Rash, plaques, nodules
Mycosis fungoides
68
Ceribriform cells
Sezary cells - mycosis fungoides
69
Abscesses in mycosis fungoides are called
Pautrier microabscesses
70
Cells in mycosis fungoides
CD4+
71
Sezary syndrome
Mycosis fungoides with blood involvement
72
Fried egg/clock face cells
multiple myeloma
73
Cytokine increased in Multiple Myeloma
IL-6
74
Ig increased in Multiple Myeloma
IgG or IgA
75
Smear findings in multiple myeloma
Roleaux
76
Complications of multiple myeloma
Hypercalcemia, Renal failure, Amyloidosis, Anemia, lytic bone lesions (CRAAB)
77
Overproduced in multiple myeloma, and related findings
Ig light chains: proteinuria, amyloidosis, proteinuria, proteinemia
78
Cause of hypercalcemia in multiple myeloma
increased OAF, activating osteoclast RANK receptor
79
Increased IgM
Waldenstrom macroglobulinemia
80
Complications in Waldenstrom macroglobulinemia
Hyperviscosity: vision and neuro Sxs, bleeding
81
Condition that can progress to multiple myeloma
MGUS
82
CD15, CD30+
RS cells in Hodgkin lymphoma
83
Better prognosis in HL predicted by
increased lymphocytes in mass
84
Young woman presents with enlarging cervical LN
Nodular sclerosing type HL
85
HL with eosinophilia; type and cause
Mixed cellularity; IL-5
86
Nodular sclerosing type HL: histology
Bands of sclerosis divide node into nodules; lacunar cells
87
Birbeck granules
"Tennis racket" shaped granules in langerhans cell histiocytosis
88
Skin involvement in langerhans cell histiocytosis is associated with
malignancy
89
Teen presents with pathological fracture; disorder and histological findings?
Eosinophilic granuloma; lots of eosinophils
90
Langerhans cell histiocytosis with scalp involvement; disorder and at-risk population
Hand-Schuller-Christian Disease; >3y/o
91
Leukemia in Downs Syndrome >5y/o
ALL
92
Hand-Schuller-Christian Disease: site of bone involvement
skull
93
rash with cystic bone defects; disorder, at risk population, prognosis
Letterer-Siwe disease;
94
S100+, CD1a+
Langerhans cells
