Paraneoplastic syndromes Flashcards
Acanthosis Nigricans
Hyperpigmented velvety plaques in axilla and neck
Gastric adenocarcinoma
Other visceral malignancies
Sign of Leser-Trélat
Sudden onset of multiple seborrheic keratoses, often with inflammatory base
GI adenocarcinoma
Other visceral malignancies
Hypercalcemia
PTHrP
SCC of lung, neck and head Renal and bladder carcinoma breast, and ovarian carcinoma \_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_\_ Elevated calcitriol
Lymphoma
Cushing syndrome
Elevated ACTH
Small cell lung cancer
Hyponatremia (SIADH)
Elevated ADH
Small cell lung cancer
Polycythemia
Elevated erythropoietin
RCC, HCC
Hemangioblastoma
Pheochromocytoma
Leiomyoma
Pure red cell aplasia
Anemia with low reticulocytes
Thymoma
Good syndrome
Hypogammaglobulinemia
Thymoma
Trousseau syndrome
Migratory superficial thrombophlebitis
Pancreatic adenocarcinoma
Nonbacterial thrombotic endocarditis
Deposition of sterile platelet thrombi on heart valves
Pancreatic adenocarcinoma
Anti-NMDA receptor encephalitis
Psych disturbances, seizures, dyskinesias, memory/language deficits, autonomic instability
Ovarian teratoma
Opsoclonus-myoclunus ataxia syndrome
“Dancing eyes, dancing feet”
KIDS: Neuroblastoma
ADULTS: Small cell lung cancer
Paraneoplastic cerebellar degeneration
Anti-purkinje antibodies (Hu, Yo, Tr antigens)
Small cell lung cancer
Gynecologic/breast cancer
Hodgkin lymphoma
Paraneoplastic encephelomyelitis
Anti-neuron antibodies (Hu antigen)
Small cell lung cancer
Lambert-Eaton myaesthenic syndrome
Anti-presynaptic Ca channel antibodies @ NMJ
Small cell lung cancer
