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Step 1 Immunology > Cancer drugs > Flashcards

Cancer drugs Flashcards

1
Q

Antimetabolite mechanism

A

Inhibit DNA synthesis in S phase

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2
Q

Topoisomerase inhibitor mechanism

A

Inhibits DNA synthesis and repair in S and G2 phase

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3
Q

DNA damaging drug mechanism

A

Inhibit DNA repair in G2 phase

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4
Q

Microtubule inhibitor mechanism

A

Interfere with mitotic spindle in M phase

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5
Q

4 Classes of Antimetabolites

A

1) Purine analogs
2) Pyrimidine analogs
3) Folic acid analogs
4) Ribonucleoside reductase inhibitors

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6
Q

Purine analogs (3)

A

CladribINE
AzathioprINE
6MP

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7
Q

Pyramidine analogs (2)

A

CytarabINE

5-FU

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8
Q

Folic Acid analog

A

MTX

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9
Q

Ribonucleoside reductase inhibitor

A

Hydroxyurea

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10
Q

2 Classes of topoisomerase inhibitor

A

Topoisomerase I inhibitors

Topoisomerase II inhibitors

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11
Q

Topoisomerase I inhibitors (2)

A

irinOTECAN

topOTECAN

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12
Q

Topoisomerase II inhibitors (2)

A

etoPOSIDE

teniPOSIDE

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13
Q

Agents causing DNA damage w/free radicals (3)

A

bleomyCIN
doxoRUBICIN
daunoRUBICIN

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14
Q

2 classes of microtubule inhibitors

A

Hyperstabilizers

Tubulin polymerization inhibitors

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15
Q

Microtubule hyperstabilizers (2)

A

PacliTAXEL

other TAXOLs

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16
Q

Tubulin polymerization inhibitors (2)

A

VINcriSTINE

VINblaSTINE

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17
Q

2 Classes of DNA crosslinking agents

A

Platinum agents

Alkylating agents

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18
Q

Platinum agents (2)

A

cisPLATIN

carboPLATIN

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19
Q

Alkylating agents (4)

A

Bisulfan
Ifosfamide
Nitrosoureas (carMUSTINE)
Cyclophosphamide

20
Q

2 Classes of growth factor antagonists

A

VEGF inhibition

EGFR inhibition

21
Q

VEGF inhibitor

A

BeVacizumab

22
Q

EGFR inhibitors (2)

A

Cetixumab

Erlotinib

23
Q

2 Classes of estrogen receptor inhibitors

A

SERMs

HER-2 mabs

24
Q

SERMS

A

tamOXIFEN

ralOXIFENe

25
Q

HER-2 mab

A

trastuzumab

26
Q

2 Classes of growth signaling in hibitors

A

BRAF inhibitors

BCR-ABL/c-kit inhibitors

27
Q

BRAF inhibitor

A

vemuRAFenib

28
Q

BCR-ABL/c-kit inhibitor

A

imatinib

29
Q

Ototoxicity

A

Cisplatin/Carboplatin

30
Q

Peripheral neuropathy

A

Vincristine

31
Q

Pulmonary fibrosis

A

Bleomycin, busulfan

32
Q

Cardiotoxicity

A

Doxorubicin, trastuzumab

33
Q

Nephrotoxicity

A

Cisplatin, carboplatin

34
Q

hemorrhagic cystitis

A

Cyclophosphamide

35
Q

Myelosuppression

A

5-FU, 6-MP, MTX

36
Q

Leucovorin

A

Rescue for folate deficiency (myelosuppression) in MTX

Enhances action of 5-FU

37
Q

6-MP and Azathioprine: enhanced toxicity with

A

allopurinol or febuxostat (xanthine oxidase inhibitors)

38
Q

Platinum agents: prevent toxicity with

A

amifostine (free radical scavenger) and saline diuresis

39
Q

Doxorubicin and daunorubicin: prevent toxicity with

A

Dexrazoxane (iron chelation)

40
Q

Cyclophosphamide and ifosfamide: prevent toxicity with

A

mesna or N-acetylcysteine (bind toxic metabolites)

41
Q

Major adverse effect of tamoxifen

A

Endometrial cancer–partial agonist (no risk with raloxifene)

42
Q

Major adverse effect in SERMs

A

thromboembolism

43
Q

Tx CML with

A

imatinib (BCR/ABL)

44
Q

Treat PV with

A

Hydroxyurea

45
Q

Tx APL with

A

ATRA

46
Q

Tx hairy cell leukemia with

A

cladribine, pentostatin

47
Q

Tx follicular lymphoma with

A

rituximab

Step 1 Immunology (13 decks)

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