Cytokines Flashcards
Secreted by Th1 cells
IFN-γ:
1) tells macrophages to kill phagocytosed pathogens
2) tells NK cells to kill virus-infected cells
3) tells all cells to express MHC/present antigens
4) inhibits Th2 differentiation
Secreted by Th2 cells
IL-4:
1) tells B-cells to grow and class-switch to IgE and IgG
2) tells CD4+ to differentiate to Th2 cells
IL-5:
1) tells B-cells to grow and class-switch to IgA
2) tells granulocytes to become eosinophils
IL-10:
1) aTENnuates immune response
2) Inhibits phagocytes
3) Decreases MHCII expression
4) Decreases Th1 cytokine expression
Secreted by all T-cells
IL-2: stimulates T-cell growth (helper, cytotoxic and Treg) and NK growth
IL-3: stimulates growth and differentiation of marrow leukocyte progenitors
ILs 1 through 6
Hot T-Bone stEAK: IL-1: fever IL-2: stimulates T-cells IL-3: stimulates bone marrow IL-4: stimulates IgE IL-5: stimulates IgA IL-6: stimulates aKute phase protein production
Secreted by macrophages
IL-1:
1) Fever
2) endothelial activation
3) chemokine secretion
IL-6:
1) Fever
2) Acute phase protein production
IL-8: PMN chemotaxis (Clean up on aisle 8)
IL-12:
Th1 differentiation, NK activation
TNF-α:
Septic shock
Cachexia in malignancy
INF-α and INF-β
Synthesized by virus infected cells, primes local uninfected cells for viral defense
Cytokines in macrophage/lymphocyte interactions?
Macrophages/APCs release IL-12, inducing Th1 differentiation.
Th1 releases IFN-γ to stimulate macrophages
Released by Regulatory T cells
IL-10, TGF-β (anti-inflammatory)
IL-12
Th1 Differentiation
