Cancer associated genes

Question 1

ALK

Answer 1

Oncogene: Receptor tyrosine kinase

Lung adenocarcinoma

Question 2

BCR-ABL

Answer 2

Oncogene: Tyrosine kinase (Philadelphia chromosome)

CML, ALL

Question 3

BCL-2

Answer 3

Oncogene: Antiapoptotic molecule

Follicular and diffuse large B-cell lymphomas

Question 4

BRAF

Answer 4

Oncogene: Serine/threonine kinase

Melanoma, non-Hodgkin lymphoma

Question 5

c-KIT

Answer 5

Oncogene: cytokine receptor

GIST

Question 6

c-MYC

Answer 6

Oncogene: transcription factor

Burkitt lymphoma

Question 7

HER2/neu (c-erbB2)

Answer 7

Oncogene: tyrosine kinase (GF receptor)

Breast and gastric carcinomas

Question 8

JAK2

Answer 8

Oncogene: Tyrosine kinase

Chronic myeloproliferative disorders

Question 9

KRAS

Answer 9

Oncogene: GTPase

Colon cancer, lung cancer, pancreatic cancer

Question 10

MYCL1

Answer 10

Oncogene: Transcription factor

Lung cancer

Question 11

MYCN

Answer 11

Oncogene: Transcription factor

Neuroblastoma

Question 12

RET

Answer 12

Oncogene: Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

Question 13

APC

Answer 13

Tumor suppressor

Colorectal cancer (FAP)

Question 14

BRCA1/BRCA2

Answer 14

Tumor suppressor: DNA repair

Breast and ovarian cancer

Question 15

CDKN2A

Answer 15

Tumor suppressor: p16, blocks G1 → S

Melanoma, pancreatic cancer

Question 16

DCC

Answer 16

Tumor suppressor

Colon cancer

Question 17

DPC

Answer 17

Tumor suppressor

Pancreatic cancer

Question 18

MEN1

Answer 18

Tumor suppressor: menin

MEN 1

Question 19

NF1

Answer 19

Tumor suppressor: Ras GTPase activator (neurofibromin)

Neurofibromatosis type 1

Question 20

NF2

Answer 20

Tumor suppressor: Merlin (Schwannomin) protein

Neurofibromatosis type 2

Question 21

PTEN

Answer 21

Tumor suppressor

Breast, prostate, and endometrial cancer

Question 22

Rb

Answer 22

Tumor suppressor: inhibits EF2, blocks G1 → S

Retinoblastoma, osteosarcoma

Question 23

TP53

Answer 23

Tumor suppressor: p53, activates p21, blocks G1 → S

Most human cancers, Li-Fraumeni syndrome

Question 24

TSC1

Answer 24

Tumor suppressor: hamartin protein

Tuberous sclerosis

Question 25

TSC2

Answer 25

Tumor suppressor: tuberin protein Tuberous sclerosis

Question 26

VHL

Answer 26

Tumor suppressor: inhibits hypoxia inducible factor 1a von Hippel-Landau disease, RCC

Question 27

WT1/WT2

Answer 27

Tumor suppressor Wilms tumor (nephroblastoma)

Question 28

Cancer associated with EBV?

Answer 28

Burkitt lymphoma Hodgkin lymphoma nasopharyngeal carcinoma Primary CNS lymphoma

Question 29

Cancer associated with HBV?

Answer 29

HCC, lymphoma

Question 30

Cancer associated with HCV?

Answer 30

HCC, lymphoma

Question 31

Cancer associated with HHV-8?

Answer 31

Kaposi sarcoma

Question 32

Cancer associated with HPV?

Answer 32

Cervical, penile and anal carcinoma (Types 16, 18) | Head and neck cancer

Question 33

Cancer associated with H pylori?

Answer 33

Gastric adenocarcinoma, MALT

Question 34

Cancer associated with HTLV-1?

Answer 34

Adult T-cell leukemia/lymphoma

Question 35

Liver fluke (Clonorchis sinensis)

Answer 35

Cholangiocarcinoma

Question 36

Schistosoma haematobium

Answer 36

Squamous cell bladder cancer