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Step 1 Immunology > Cancer associated genes > Flashcards

Cancer associated genes Flashcards

1
Q

ALK

A

Oncogene: Receptor tyrosine kinase

Lung adenocarcinoma

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2
Q

BCR-ABL

A

Oncogene: Tyrosine kinase (Philadelphia chromosome)

CML, ALL

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3
Q

BCL-2

A

Oncogene: Antiapoptotic molecule

Follicular and diffuse large B-cell lymphomas

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4
Q

BRAF

A

Oncogene: Serine/threonine kinase

Melanoma, non-Hodgkin lymphoma

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5
Q

c-KIT

A

Oncogene: cytokine receptor

GIST

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6
Q

c-MYC

A

Oncogene: transcription factor

Burkitt lymphoma

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7
Q

HER2/neu (c-erbB2)

A

Oncogene: tyrosine kinase (GF receptor)

Breast and gastric carcinomas

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8
Q

JAK2

A

Oncogene: Tyrosine kinase

Chronic myeloproliferative disorders

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9
Q

KRAS

A

Oncogene: GTPase

Colon cancer, lung cancer, pancreatic cancer

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10
Q

MYCL1

A

Oncogene: Transcription factor

Lung cancer

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11
Q

MYCN

A

Oncogene: Transcription factor

Neuroblastoma

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12
Q

RET

A

Oncogene: Tyrosine kinase

MEN 2A and 2B, medullary thyroid cancer

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13
Q

APC

A

Tumor suppressor

Colorectal cancer (FAP)

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14
Q

BRCA1/BRCA2

A

Tumor suppressor: DNA repair

Breast and ovarian cancer

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15
Q

CDKN2A

A

Tumor suppressor: p16, blocks G1 → S

Melanoma, pancreatic cancer

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16
Q

DCC

A

Tumor suppressor

Colon cancer

17
Q

DPC

A

Tumor suppressor

Pancreatic cancer

18
Q

MEN1

A

Tumor suppressor: menin

MEN 1

19
Q

NF1

A

Tumor suppressor: Ras GTPase activator (neurofibromin)

Neurofibromatosis type 1

20
Q

NF2

A

Tumor suppressor: Merlin (Schwannomin) protein

Neurofibromatosis type 2

21
Q

PTEN

A

Tumor suppressor

Breast, prostate, and endometrial cancer

22
Q

Rb

A

Tumor suppressor: inhibits EF2, blocks G1 → S

Retinoblastoma, osteosarcoma

23
Q

TP53

A

Tumor suppressor: p53, activates p21, blocks G1 → S

Most human cancers, Li-Fraumeni syndrome

24
Q

TSC1

A

Tumor suppressor: hamartin protein

Tuberous sclerosis

25
Q

TSC2

A

Tumor suppressor: tuberin protein

Tuberous sclerosis

26
Q

VHL

A

Tumor suppressor: inhibits hypoxia inducible factor 1a

von Hippel-Landau disease, RCC

27
Q

WT1/WT2

A

Tumor suppressor

Wilms tumor (nephroblastoma)

28
Q

Cancer associated with EBV?

A

Burkitt lymphoma
Hodgkin lymphoma
nasopharyngeal carcinoma
Primary CNS lymphoma

29
Q

Cancer associated with HBV?

A

HCC, lymphoma

30
Q

Cancer associated with HCV?

A

HCC, lymphoma

31
Q

Cancer associated with HHV-8?

A

Kaposi sarcoma

32
Q

Cancer associated with HPV?

A

Cervical, penile and anal carcinoma (Types 16, 18)

Head and neck cancer

33
Q

Cancer associated with H pylori?

A

Gastric adenocarcinoma, MALT

34
Q

Cancer associated with HTLV-1?

A

Adult T-cell leukemia/lymphoma

35
Q

Liver fluke (Clonorchis sinensis)

A

Cholangiocarcinoma

36
Q

Schistosoma haematobium

A

Squamous cell bladder cancer

Step 1 Immunology (13 decks)

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