Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pathophysiology 1 > WBC Malignancies > Flashcards

WBC Malignancies Flashcards

1
Q

What is a circulating tumor in blood and bone marrow?

A

Leukemia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is a malignancy that is localized in lymph tissue?

A

lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is a plasma cell myeloma?

A

WBC malignancy, localized tumors found in bony structures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

In WHO classification scheme, what is the major category?

A

Cell type (myeloid or lymphoid)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

WHat do myeloproliferative diseases involve?

A

Too many of the normal cells?

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are myelodysplastic/ proliferative diseases?

A

Too many abnormal looking cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are myelodysplastic syndromes?

A

Abnormal looking cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are types of lymphoid neoplasms?

A

B-cell neoplasm
T & NK cell neoplasm
Hodgkin disease
Non-Hodgkin lymphoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What is the cause of leukemia?

A

Unknown, however some viruses (HTLV-1, HIV, EBV), and Radiation have shown to have a casual relationship

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is involved in bone marrow suppression ?

A

Leucopenia (lack of normal luekocytes)
Anemia
Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the key to diagnosing leukemia?

A

CBC, then bone marrow lymph node sample

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is the post-remission phase of chemotherapy?

A

Used to eliminate undetected cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is an allogeneric bone marrow transplant?

A

From a bone marrow donation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is a autologous bone marrow transplant?

A

Reinfusion of your own stem cells after treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What cells are involved in myeloid neoplasms?

A

monocytes
granular leukocytes
RBCs
megakaryocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are 3 examples of myleoproliferative disorders? (normal cells, just too many of them?

A

CML
PV
Essential thrombocythemia
(good prognosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What type of myeloid neoplasm is AML?

A

Myelodysplastic
Cells morphologically and functionally
(bad prognosis) abnormals

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

When it typical onset for chronic myeloid leukemia?

A

40-50 years

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What chromosome do the malignant granulocytes carry in CML?

A

Philadelphia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the fusion gene bcr abl ?

A

CML (because of Philadelphia chromosome)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What are two signs of CML?

A

high granulocyte count & splenomegaly

22
Q

What is the only treatment for CML?

A

allogeneic marrow transplant (from close relative)

23
Q

What type cells is transformed in AML?

A

myeloid stem cell

24
Q

Which type of leukemia has subtypes (M0-M7)

A

Acute Myeloid Leukemia

25
Q

What is the most common version of AML

A

Acute granulocytic leukemia

26
Q

In AML, do the Philadelphia chromosome help or hurt the survival rate of the person?

A

Hurts- reduced to about 5%

27
Q

What cell type transformations are involved in lymphoid neoplasms?

A

B, T, NK cells

28
Q

What 2 subgroups are lymphoid neoplasms divided into?

A

Precursor cell neoplasms

Mature Cell neoplasm

29
Q

WHat is a precrusor cell neoplams (lymphoid)?

A

arrest development early in blast stage

30
Q

What is a mature cell neoplasm (lymphoid)?

A

More differentiated, often peripheral sites- more functionality

31
Q

Chronic lymphoid leukemia normally has what precursor?

A

B-cell (5% T cell- which is more aggressive)

32
Q

Loss of production of what with B cell CLL?

A

antibodies

33
Q

What is ALL?

A

Acute lymphoblastic Leukemia/ Lymphoma

34
Q

ALL has abnormal of what cell types?

A

Lymphoblasts (immature)

35
Q

ALL is a disorder primarily of who?

A

Children

36
Q

What cell phenotype is hairy cell leukemia?

A

B cell phenotypes that have hair like projections

37
Q

What gender is more affected with hairy cell leukemia?

A

Males (5:1 ratio)

38
Q

Malignant cells in plasma cell myeloma all come from…

A

One B cell clone

antibodies accumulate in blood

39
Q

Where do the extra antibodies in PCM (plasma cell myeloma) go?

A

Appear in the urine

Bence Jones protein

40
Q

What are Reed-Sternberg cells found in?

A

Hodgkin Disease (malignant lymphoma)

41
Q

Where do Reed-Sternberg cells come from?

A

B cells in lymph nodes

42
Q

What virus is commonly found in RS cells?

A

Epstein Barr Virus

43
Q

What type spread pattern is found in Hodgkin Disease?

A

Continuos lymphatic pathways

44
Q

2 types of Hodgkin Disease?

A
  1. rare lymphocyte predominance types (5%)

2. Classical- 4 subtypes (95%)

45
Q

What is the A version of a stage in Hodgkin Disease?

A

No clinical symptoms

46
Q

What is the B version of a stage in Hodgkin Disease?

A

Clinical symptoms at staging (night sweats, pruritus, weight loss, malaise)

47
Q

Stage 1 Hodgkin lymphoma?

A

1 lymph node effected

48
Q

Stage III Hodgkin lymphoma?

A

Lymph nodes on either side of the diaphragm affected

49
Q

Which type of lymphoma has a more common occurance of extranodal disease (GI, testes, bone marrow)

A

Non-Hodgkins Lymphoma

50
Q

Which type of lymphoma usually has mediastinal involvement?

A

Hodgkins lymphoma

Pathophysiology 1 (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions