Water Soluble Vitamins Flashcards
Digesting and Absorbing water soluble vitamins
WSVs are hydrolyzed in the stomach and then absorbed in the upper part of the SI (other than B12, which is in the ileum), and then is sent into portal vein, and then transported to the liver where they are either stored (B12) or go straight into systemic circulation.
- Any excess WSVs are excreted in the urine.
What is the role of most vitamins?
They function as components of specific coenzymes.
B vitamin mnemonic
The Rhythm Nearly Proved Fully Contagious
What’s its of foods haveThiamine ?
Whole grain products
What vitamin will often be deficient in alcoholics?
Thiamine
Functions of Thaimine
Acts in the TCA cycle to activate pyruvate dehydrogenase, alpha ketoglutarate dehydrogenase, and branched-chain alpha-ketoacid dehydrogenase. Essential for normal functioning of heart, muscles, and nervous system.
Symptoms of B1 deficiency
Beriberi
- general symptoms - poor appetite, irritability, apathy, confusion, and weight loss
Beriberi
2 types, Both due to a B1 deficiency, wet and dry:
Wet - edema due to cardiovascular problems
Dry - muscle wasting, neurological disorders
What foods have B2 (riboflavin) in them?
Milk products, liver
WHat form of riboflavin will we see in the body?
FAD (flavin adenine dinucleotide) mostly but some FMN (flavin mononucleotide)
Functions of FADH2/riboflavin/B2
They act as prosthetic groups in oxidative phosphorylation and the TCA cycle. HEavily involved in Redox reactions.
Deficiency of B2
Inflammation of membranes –> sore throat, cheilosis, glossitis, stomatitis, seborrheic dermatitis, bloodshot eyes, sensitivity to light.
- cheilosis is cracks at corners of mouth
- stomatitis - inflammation of mouth and lips.
Seborrheic dermatitis - causes flaky, white to yellowish scales on oily areas such as the scalp, face, or inside of ear.
Where can you find B3 (niacin)
Protein rich foods
What form of B3 will we mostly see in the body?
Nicotinamide, NAD, NADP.
- can also be made from tryptophan in the body..
Function of B3
Redox reactions