Gibeny - Histo Of Gallbadder, Pancreas, And Liver Flashcards
What are the 4 cells of the liver
Hepatocytes
Fenestrated endotheliel cells
Macrophages (Kupffer cells)
Lipocytes
What are the three things in the portal triad?
BPH
- bile duct, portal vein, hepatic artery
What does the portal vein empty into?
The central vein through hepatic sinusoids
What is one unit o the liver called?
Lobules, clearly defined with CT and connects 4 portal triads.
Hepatic sinusioud
Carry from from both the hepatic artery and portal vein to the central vein.
Bile caniliculi
Bile produced by the hepatocyte is secreted into the bile canaliculi and flows towards the bile duct.
Liver Acinus
Another functional unit of the liver. This time it is from one central vein to another central vein. It makes a box with each central vein being corners and 2 portal triads being the other corners.
WHere are the various zones of the acinus?
Zone 1 - hepatocytes closes to the center of acinus receive blood richest in O2 and nutrients.
Zone 3 - hepatocytes nearest the central vein receive blood low in O2 andd nutrients and most susceptible to toxins.
What is a good indicator that you are looking at a hepatocyte?
You will be able to see glycogen within the hepatocytes that stain magenta in a best carmine stain.
Space of Disse
The space between hepatocytes and sinusoids (perisinosoidal space).
What cells line the sinusoids
Kupffer cells sand gene started endothelial Cells.
Hepatic lipocyteq
Located in the perisinusoidal space.
- it stores vitamin A and lipid. Under pathological conditions this cell synthesizes and secretes collagen which contributes to cirrhosis.
How do. Things get from the pancreas to t he duodenum?
Through the pancreatic duct, which empties its enzymes into the common bile duct.
Islets of Langerhans
Form discrete clusters in the pancreas. Light staining and often have fenestrated blood vessels in them.
The exocrine pancreas is under the control of what?
CCK secreted by DNES cells.
Exocrine pancreas vs endocrine pancreas
Exocrine secreted into the duodenum
Endocrine secretes into the bloodstream
Centroacinar cells
Beginning of the duct system. The beginning of the intercalated ducts in the pancreas. They stain lighter than the dark acinar cells.
Intercalated ducts of the pancreas
About the same size as the acinus but stains much lighter.
- releases HCO3 and H20 When trigger by secretin.
Interlobular duct
Lined by low columnar epithelium surrounded by dense CT. They Drain into the pancreatic duct.
Histology of the gallbladder
Lined with simple columnar epithelium with short microvilli and NO goblet cells.
- Mucosa has many folds.
- Many lymphocytes and plasma cells.
- thin irregular muscularis externa.
- KEY HISTOLOGICAL FEATURE - presence of Rokitansky-Aschoff sinuses if they are in the image. .
Blood supply of the liver
25%. Hepatic artery
75% portal vein
