Gibeny - Histo Of Gallbadder, Pancreas, And Liver

Question 1

What are the 4 cells of the liver

Answer 1

Hepatocytes
Fenestrated endotheliel cells
Macrophages (Kupffer cells)
Lipocytes

Question 2

What are the three things in the portal triad?

Answer 2

BPH

- bile duct, portal vein, hepatic artery

Question 3

What does the portal vein empty into?

Answer 3

The central vein through hepatic sinusoids

Question 4

What is one unit o the liver called?

Answer 4

Lobules, clearly defined with CT and connects 4 portal triads.

Question 5

Hepatic sinusioud

Answer 5

Carry from from both the hepatic artery and portal vein to the central vein.

Question 6

Bile caniliculi

Answer 6

Bile produced by the hepatocyte is secreted into the bile canaliculi and flows towards the bile duct.

Question 7

Liver Acinus

Answer 7

Another functional unit of the liver. This time it is from one central vein to another central vein. It makes a box with each central vein being corners and 2 portal triads being the other corners.

Question 8

WHere are the various zones of the acinus?

Answer 8

Zone 1 - hepatocytes closes to the center of acinus receive blood richest in O2 and nutrients.
Zone 3 - hepatocytes nearest the central vein receive blood low in O2 andd nutrients and most susceptible to toxins.

Question 9

What is a good indicator that you are looking at a hepatocyte?

Answer 9

You will be able to see glycogen within the hepatocytes that stain magenta in a best carmine stain.

Question 10

Space of Disse

Answer 10

The space between hepatocytes and sinusoids (perisinosoidal space).

Question 11

What cells line the sinusoids

Answer 11

Kupffer cells sand gene started endothelial Cells.

Question 12

Hepatic lipocyteq

Answer 12

Located in the perisinusoidal space.
- it stores vitamin A and lipid. Under pathological conditions this cell synthesizes and secretes collagen which contributes to cirrhosis.

Question 13

How do. Things get from the pancreas to t he duodenum?

Answer 13

Through the pancreatic duct, which empties its enzymes into the common bile duct.

Question 14

Islets of Langerhans

Answer 14

Form discrete clusters in the pancreas. Light staining and often have fenestrated blood vessels in them.

Question 15

The exocrine pancreas is under the control of what?

Answer 15

CCK secreted by DNES cells.

Question 16

Exocrine pancreas vs endocrine pancreas

Answer 16

Exocrine secreted into the duodenum

Endocrine secretes into the bloodstream

Question 17

Centroacinar cells

Answer 17

Beginning of the duct system. The beginning of the intercalated ducts in the pancreas. They stain lighter than the dark acinar cells.

Question 18

Intercalated ducts of the pancreas

Answer 18

About the same size as the acinus but stains much lighter.

- releases HCO3 and H20 When trigger by secretin.

Question 19

Interlobular duct

Answer 19

Lined by low columnar epithelium surrounded by dense CT. They Drain into the pancreatic duct.

Question 20

Histology of the gallbladder

Answer 20

Lined with simple columnar epithelium with short microvilli and NO goblet cells.

• Mucosa has many folds.
• Many lymphocytes and plasma cells.
• thin irregular muscularis externa.
• KEY HISTOLOGICAL FEATURE - presence of Rokitansky-Aschoff sinuses if they are in the image. .

Question 21

Blood supply of the liver

Answer 21

25%. Hepatic artery

75% portal vein