Warfarin & Heparin Flashcards
1
Q
Warfarin
A
Prolongs extrinsic pathway Requires >3 days to work Inhibits natural anti-coagulants Cytochrome P450 Control affected by binding to albumin
2
Q
Reversal of warfarin
A
activated prothrombin complex (if life threatening)
vit K
fresh frozen plasma
3
Q
Reversal of heparin
A
protamine sulfate
4
Q
Complication of unfractionated heparin
A
HIT - heparin induced thrombocytopenia
Monitored by APTT ratio (2x normal)
5
Q
When to use LMW heparin
A
Creatinine clearance of >30 ml/min
used for thromboprophylaxis
