Blood unknown Flashcards
What do II, VII, IX and X require for acitvation
Ca2+
What does ATIII do
Blocks the activity of factor IX and X
What drugs are used for arterial diseases
Fibrinolytics and anti platelets
What can liver dysfunction/cirrhosis or hepatitis cause
Clotting deficiency
What does warfarin inhibit
Protein C and S
How does plasmin mature
tPA and when mature it lyses clots
What do eosinophils and basophils express and where are they most active
FcERI
At site of allergic reaction
What do eosinophils/basophils look like
Lobed nuclei and granulated cytoplasm
Basophils have blue granules
Eosinophils have red granules
How long do neutrophils last
8 hours - 4 days
What happens to monocytes after release from the bone marrow
Circulate in blood stream and enlarge
Migrate to tissues one day after release from bone marrow
There is a reservoir of monocytes in spleen
Macrophages 5-10 x larger than monocytes
Lifespan of macrophages: months to years
Adhesion molecules
P selectin and E selectin on endothelium recognised by leukocytes
ICAMS on endothelium recognised by integrins on leukocytes
Adhering monocytes stimulated by MCP-1 to enter intima
Pattern recognition receptors
Macrophage mannose receptor
Scavenger receptor
Toll like receptors
Cytokines released from activated macrophages
IL-1 beta
TNF alpha
IL-6
Examples of inherited vascular disorders
Haemorrhagic telangiectasia
Ehlers Danlos syndrome
Examples of acquired vascular disorders
Scurvy
Senile
Steroids
