Warfarin Flashcards
1
Q
What type of drug is warfarin?
A
oral anticoagulant
2
Q
What does warfarin inhibit?
A
epoxide reductase preventing reduction of vitamin K to its active hydroquinone form
3
Q
Which clotting factors is warfarin a cofactor for the carboxylation of?
A
10, 9, 7, 2 (1972) and protein C
4
Q
What factors may increase the function of warfarin?
A
- liver disease
- P450 enzyme inhibitorzz (amiodarone, ciprofloxacin)
- cranberry juice
- drugs that displace warfarin from plasma albumin (NSAIDs)
- inhibit platelet function (NSAIDs)
5
Q
What are the side effects?
A
- haemorrhage
- tetrogenic
- skin necrosis
- purple toes
