Adenosine Diphosphate (ADP) receptor inhibitors Flashcards
1
Q
What are some examples of ADP receptor inhibitors?
A
- clopidogrel
- prasugrel
- ticagrelor
- ticlopidine
2
Q
What type of activating factor are ADP receptor inhibitors?
A
platelets
3
Q
What are ADP receptor inhibitors mediated by?
A
G-coupled receptors P2Y1 and P2Y12
4
Q
What is the main target for ADP receptor inhibitors?
A
P2Y12 receptor
5
Q
What is the main adverse effect of ticagrelor?
A
dyspnoea
6
Q
What type of drugs does clopidogrel interact with reducing antiplatelet effects?
A
PPIs
7
Q
What drug does omeprazole interact with reducing antiplatelet effects?
A
esomeprazole
8
Q
Which patients should prasugrel NOT be used in?
A
- suffered a previosu stroke or TIA
- high risk of bleeding
9
Q
Which patients should ticagrelor NOT be used in?
A
- high risk bleeding
- intracranial haemorrhage
- severe hepatic dysfunction
- asthma/COPD
