Nitrates Flashcards
1
Q
What type of drugs are nitrates?
A
vasodilators
2
Q
What is it used in the management of?
A
- angina
- acute HF
3
Q
What is the mechanism of action of nitrate?
A
release of nitric oxide in smooth muscle, activating guanylate cyclase converts GTP to cGMP resulting in a fall in Ca2+ levels
4
Q
What is the mechanism of action of nitrates in angina?
A
coronary arteries dilate and reduced venous return -> reduces LV work -> reducing myocardial oxygen demand
5
Q
What are the side effects of nitrates?
A
- hypotension
- tachycardia
- headaches
- flushing
