ACE inhibitors Flashcards
1
Q
Which patients are ACEi the first line treatment for?
A
- younger patients with hypertension
- patients with heart failure
2
Q
Which patients are ACEi not effective in?
A
Afro-Caribbean patients
3
Q
What else can ACEi be used for?
A
- diabetic nephropathy
- secondary prevention of ischaemic heart disease
4
Q
What do ACEi inhibit?
A
conversion of angiotensin I to angiotensin II
5
Q
What are ACEI activated by?
A
phase 1 metabolism in the liver
6
Q
What are the side effects of ACEi?
A
- cough
- angioedema
- hyperkalaemia
- first-dose hypertension (common in those taking diuretics)
7
Q
Who should ACEi be avoided in?
A
pregnant people
8
Q
What are the contraindications of ACEi?
A
- renovascular disease
- aortic stenosis
- hereditary of idiopathic angioedema
9
Q
What other drugs do ACEi interact with and what can it cause?
A
high-dose diuretics
- hypertension
10
Q
How are ACEi monitored?
A
checking U&E
11
Q
What are some examples of ACEi?
A
- rampiril
- lisinopril
