W9 - Textbook Flashcards
What is it called when the immune system can become functionally depressed?
Immunodepression
What may immunodepression result in?
⬆️ susceptibility to infection
especially URTIs.
What can lead to immunodepression in athletes?
Stress i.e heavy training schedule + comp
What activates the innate immune system?
When an infectious agent tries to enter the body
The innate immune system is known as the 1st line of defence, what 3 general mechanisms in this have the common goal of restricting microorganism entry into the body?
- Physical/Structural barriers
- Chemical barriers
- Phagocytic cells
Give examples of physical/structural barriers in the 1st line defence of the innate immune system
Skin
Epithelial linings
Mucosal secretions
Give examples of chemical barriers in the 1st line defence of the innate immune system
pH of bodily fluids
Soluble factors
Give examples of phagocytic cells in the 1st line defence of the innate immune system
Neutrophils
Macrophages or monocytes
What activates the adaptive/acquired/specific immune system?
Infection due to failure of the innate immune system
Which lymphocytes play a big role in the adaptive/acquired/specific immune system?
T-lymphocyte
B-lymphocyte
What do T-lymphocyte and B-lymphocyte do?
Their receptors recognise the foreign mol (antigens) and cause specificity + memory that enable the immune system to create an augmented response when the body is REinfected by the SAME pathogen.
What is a pathogen?
Organism that causes disease
Where do WBCs (leukocytes) comes from?
Stem cells of bone marrow
What do leukocytes consist of?
Granulocytes (60-70%)
Monocytes (10-15%)
Lymphocytes (20-25%)
What protein do all T-lymphocytes express on the cell surface?
What does this mean they are designated as?
CD3
Designated as: CD3+