w6- oxygen delivery

Question 1

what are some of the mechanisms your body can employ to allow for for oxygen delivery to tissues during anemia until the critical Hbthreshold is reached

Answer 1

• Increase in cardiac output (due to decreased blood viscosity and increased heart rate)
• Increase in tissue oxygen extraction
• Redistribute blood flow to areas of high demand
• Increase in red cell BPG level

Question 2

how will shivering interfere with the pulse ox

Answer 2

it will interfere with the ability of the machine to differentiate arterial versus venous blood from the pulsatile nature

Question 3

what is the critical Hb threshold

Answer 3

the threshold that anemia diminishes the critical O2 delivery to the tissues

Question 4

what are the 3 ways in which CO2 is carried in the blood

what is the role of carbonic anhydrase

Answer 4

dissolved Co2, bicarb and carbamate

catalyzes the conversion of Co2 to bicarb

Question 5

how is the production of EPO upregulated by by hypoxia

what is a side effect of doping with EPO

Answer 5

HIFa is no longer maked by O2 dependendent proyl hydroxylase to be degreaded by VHL E3–> dimerizes with HIF b –> TF –> EPO receptor in bone marrow to stimulate more RBC production and also inhibits hepcidin (increase iron absorption) and also stimulates transferin (iron transport)

increases viscosity ( which can also decrease CO)