Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Block 1 > W5: T cell > Flashcards

W5: T cell Flashcards

1
Q

T progenitor cells migrate from __ to __ for development

A

bone marrow to thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Thymus stroma is epithelial in origin and develops from __.

A

3rd pharyngeal pouch

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Thymus: location of

Positive selection
Negative selection

A

Positive: cTEC (cortical thymic epithelical cell)

Negative mTEC (medullary

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What happens during:

Positive selection
Negative selection

A

TCR that binds to self-MHC on cTEC survive

TCR that binds too tightly to self antigen on mTEC die (apoptosis)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Negative selection happens in __ of thymus, where the cells express __ gene.

A

medulla, AIRE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Central tolerance is established in the __ of thymus via +/- selection.

A

medulla, - selection

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is RAG gene? What is AIRE gene? Where are they located and what do they facilitate?

A

RAG - recombination activating gene inside T cell that facilitate genetic diversity of TCR

AIRE - autoimmune regulator protein gene inside mTEC that facilitates Central tolerance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

+ and - selection screens affinity of __ to self peptides

A

TCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Lineage commitment happens in the __ of thymus

A

medulla

recognition of MHC I - CD8 T cell

MHC II - CD4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Central tolerance mediated by 2 cells in medulla:

A

mTEC, Dendritic cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Mutation in __ gene leads to autoimmune disease

A

AIRE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is APS Type I (Autoimmune Polyendocrinopathy Syndrome)

A

autoimmune response to own cytokines, caused by mutation in AIRE gene

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

DiGeorge Syndrome patients completely lack __ due to deletion of __.

A

T cells; 3rd and 4th pharyngeal pouches

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Both __ and __ arise from 3rd pharyngeal pouch

A

parathyroid, thymus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

During thymic selection, the affinity for __ to MHC is assessed

A

TCR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Primary and Secondary lymphoid organs

A

primary: thymus, bone marrow
secdonary: spleen, lymph node

17
Q

Naive T cells enter the lymph node through __ circulation via opening __.

A

arterial, HEVs (high endothelial venules)

18
Q

Peyer’s patches are lymphoid nodules in __.

A

small intestine

19
Q

T cells enter lymph node via __ exit via __.

circulations

A

arterial circulation

lymphatics

20
Q

Naive T cells are activated in lymph node when it meets __.

A

APC: DC

21
Q

Activation of T cell: require how many signals (from DC)

CD8:
CD4:

A

CD8: 2
CD4: 3

TCR-MHC
co-stimulation
(+cytokines for CD4)

22
Q

T cell differentiation upon activation:

CD8:
CD4:

A

CD8: cytotoxic T cells
CD4: helper T cells

23
Q

CD4 T cells can become (5 types)

A 
Th1
Th2
Th17
Tfh
Treg
24
Q

Maintaining Self Tolerance?

Th1
Th2
Th17
Tfh
Treg
A

Treg

25
Q

Activate macrophage?

Th1
Th2
Th17
Tfh
Treg
A

Th1

26
Q

recruit and activate neutrophil?

Th1
Th2
Th17
Tfh
Treg
A

Th17

27
Q

facilitate long term humoral immunity and B cell class switching?

Th1
Th2
Th17
Tfh
Treg
A

Tfh

28
Q

Anti-inflammatory?

Th1
Th2
Th17
Tfh
Treg
A

Treg

29
Q

Triggered by parasites?

Th1
Th2
Th17
Tfh
Treg
A

Th2

30
Q

Secrete IFN-gamma?

Th1
Th2
Th17
Tfh
Treg
A

Th1

“IFNγ is an important activator of macrophages and inducer of Class II major histocompatibility complex (MHC) molecule expression.”

31
Q

TGFb and IL-10 are anti-inflammatory cytokines, secreted by __ cell

A

Treg

Research paper - “The role of IL-10 and TGF-beta in the differentiation and effector function of T regulatory cells.”

32
Q

Mutation in the STAT3 gene leads to recurrent bacterial and fungal infections. Why? Disease name?

A

failure to make Th17 efficiently; Jobs Disease

33
Q

IPEX disease is caused by mutation in FOXP3 gene that leads to autoimmune enteropathy. Why?

A

failure to make Treg efficiently

34
Q

Th17 deficiency leads to:

Treg deficiency leads to:

A

Th17: Jobs (STAT3)

Treg: IPEX (FOXP3)

35
Q

Differentiation of CD4 T cells is directed by __.

A

cytokines

36
Q

What is HEVs and where is it located

A

High endothelial venule in the lymph node; where naive T cell enters via arterial circulation

Block 1 (26 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions