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W3 Pathology of neoplasia Flashcards

1
Q

What are IHC markers for GIST?

A

DOG-1+
KIT/CD117+/-
SMA+/-

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2
Q

What are IHC markers for hemangiosarcoma/
lymphangiosarcoma?

A

Factor VIII/vWF+
CD31/PECAM-1+

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3
Q

What are the IHC markers for histiocytic sarcoma and what is its cell of origin?

A

IHC markers:
CD1a+
CD11c+
CD18+
Iba1+
Lysozyme+/-

Interstitial dendritic cells

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4
Q

What are the IHC markers for leiomyoma, leiomyosarcoma?

A

SMA+
Desmin+/-

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5
Q

What are the IHC markers for B-cell LSA?

A

CD20+
Pax5+
CD79a+
CD18+/-

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6
Q

What are the IHC markers for T-cell LSA?

A

CD3+
CD18+/-

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7
Q

What are the IHC markers for null cell LSA?

A

round cell tumor that is negative for all markers

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8
Q

What are the IHC markers for MCT?

A

Tryptase+
KIT/CD117+

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9
Q

What are the IHC markers for melanoma?

A

S-100+
Vimentin+
Melan-A+/-
PNL2+/-
Tyrosinase+/-
TRP-1+/-
TRP-2+/-
NSE+/-

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10
Q

What are the IHC markers for mesothelioma?

A

Cytokeratin+/-
Vimentin+/-

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11
Q

What are the IHC markers for neural astrocytic tumors (ie, astrocytoma, glioblastoma, oligodendroglioma)?

A

GFAP+
S-100+/-
Olig2+/-

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12
Q

What are the IHC markers for neuroendocrine tumors?

A

NSE+
Chromogranin A+/-
Synaptophysin+/-

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13
Q

What are the IHC markers for plasma cell tumors?

A

MUM-1/IRF4+
CD18+/-
CD79a+/- (Pax5-)

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14
Q

What are the IHC markers for rhabdomyoma, rhabdomyosarcoma? Specify localization and which have good sensitivity and specificity for undifferentiated tumors in humans.

A

IHC markers:
Vimentin+ (cytoplasm)
Desmin+ (cytoplasm)
Myoglobin+/- (cytoplasm)
MyoD1+/- (nuclear)
Myogenin+/- (nuclear)

High sensitivity/specificity in humans:
- Myogenin
- MyoD1

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15
Q

What are the IHC markers for synovial cell sarcoma?

A

Vimentin+
Cytokeratin+/-

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16
Q

What are the IHC markers for a thyroid tumor (follicular epithelial origin)?

A

Thyroglobulin+
TTF-1+

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17
Q

What are the IHC markers for a thyroid tumor (C-cell/parafollicular cell origin)?

A

TTF-1+
Calcitonin+
Chromogranin A+
Synaptophysin+
NSE+
Thyroglobulin-

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18
Q

What are lymphatic endothelial-specific markers?

A

Prox-1 and LYVE-1

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19
Q

_______ is expressed on all leukocytes but its expression is typically highest on, yet not specific for, histiocytic cells.

A

CD18

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20
Q

_____ expression is shown in monocyte/macrophage lineage, dendritic cells, and associated tumors. What is the localization?

A

Iba1
cytoplasm

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21
Q

What are the IHC markers for hemophagocytic histiocytic sarcoma?

A

CD11d/CD18
CD1a (low)

22
Q

_____ is an additional marker for cutaneous and systemic histiocytosis, indicating dermal dendritic cell origin.

A

CD90/Thy-1+

23
Q

______ confirms myogenic origin but does not differentiate between smooth, striated, or cardiac muscle.

24
Q

What is the melanoma IHC “cocktail” that is reported to have excellent specificity and sensitivity?

A

PNL2, Melan-A, TRP-1 and TRP-2

25
What diagnostic test may demonstrate microvilli for mesothelioma?
TEM
26
Astrocytomas are glial tumors, as are oligodendrogliomas; however, oligodendrogliomas are negative for ____ (IHC marker).
GFAP
27
_______ is a histochemical stain for a granular cell tumor, which highlights carbohydrates within cytoplasmic lysosomes.
Periodic acid-Schiff (PAS)
28
What are histochemical stains for liposarcoma and other lipid-rich neoplasms, highlighting lipid?
Oil Red-O, Sudan stains (black, III, IV)
29
What are histochemical stains for mast cell tumors?
Toluidine blue, Giemsa, PAS
30
What are histochemical stains for melanoma, which highlight melanin?
Fontana-Masson
31
What are the histochemical stains for neuroendocrine tumors, which highlight cytoplasmic granules?
Silver stains (Pascual's, Grimelius, Sevier-Munger), Churukian Schenk
32
What histochemical stain can be used for plasma cell tumors and APOT, highlighting amyloid?
Congo red
33
What histochemical stains can be used for rhabdomyosarcoma, highlighting myocyte cross striations?
phosphotungstic acid-hematoxylin (PTAH)
34
What histochemical stain can be used for fibrocytic tumors, highlighting collagen?
Masson Trichrome
35
What histochemical stain can be used for myxoma or myxosarcoma, highlighting proteoglycans?
Alcian Blue
36
One study reported that ____% of previously "negative" lymph nodes could be reclassified after comprehensive sectioning and staining.
25%
37
A study applying WHO system of lymphoma classification demonstrated an overall accuracy of ___% among 17 pathologists.
83%
38
A study of low-grade MCT in dogs found that ___% of margin outcomes changed according to sectioning technique.
23%
39
Cadaveric canine skin undergoes a notable tissue length reduction ("shrinkage") immediately after excision - approximately ___% for circumferential measurements.
14%
40
For cutaneous biopsy specimens, shrinkage can be up to ___%.
30%
41
In 1 study, the reduction between the in vivo grossly normal surgical margin and the histologic tumor free margin was noted to be as much as ____ mm for canine MCTs and ____ mm for STS.
MCT: 30mm STS: 24mm
42
One study of 13 cats with ISS who had tumor recurrence reported incomplete histologic margins in ____.
1
43
Dogs with incompletely excised STS have been reported as _____ times more likely to experience local recurrence.
10.5 times
44
One study found a median standard deviation of almost ____ in circumferential margins for MCTs.
2mm
45
One study of low-grade MCT and STS showed circumferential and deep infiltration was _____ mm for MCTs and ____ mm for STS from sub-gross tumor edge.
MCT 4mm STS 2 mm
46
In veterinary medicine, diagnostic disagreement between 1st and 2nd opinion pathology has been reported to be as high as ___%. Disagreement was up to __% for differences that would affect prognosis and treatment choices.
- complete: 19% - affect prognosis/tx: 37%
47
What histochemical stain highlights iron?
Prussian Blue
48
Canine cutaneous histocytoma arises from ________ cell. What are the IHC markers?
Langerhans cells: CD1a, CD11c/CD18 and E-cadherin
49
Feline Langerhans cell histiocytosis involves infiltration of the _________ with what IHC markers? _______ granules are observed as well.
- lungs - CD18, E-cadherin, +/- CD1a and contain Birbeck’s granules
50
What are the IHC markers for cutaneous/systemic histiocytosis in dogs?
CD1a, CD4, CD11c/CD18, CD90
51
What are the IHC markers for feline progressive histiocytosis?
CD1a, CD11b/CD18, CD5 (50%)
52
What are the IHC markers for dendritic cell leukemia?
CD1a, CD11c/CD18

Oncology Specialty Boards (31 decks)

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