Ocular Tumors Flashcards
______ and _____ of the haired skin and eyelid margin make up 76% of canine eyelid tumors.
Benign adenomas and melanoma
________n comprises up to two-thirds of
feline eyelid and third eyelid tumors.
SCC
______ are the most common malignant tumor of the conjunctiva in dog.
melanoma
The majority of canine eyelid or conjunctival tumors are histologically _____ whereas the majority in cats are _____.
benign
malignant
SCC of the _______ may more readily invade the orbit than other locations.
third eyelid
Adenocarcinoma of the third eyelid may mimic _______.
cherry eye
Canine conjunctival melanomas
have been reported to recur locally after surgical excision in ___% of cases, and at least ____% of the dogs experience orbital invasion or spread to the regional lymph nodes or lungs.
55%
17%
Regrowth after local surgical excision occurs in approximately ___% of patients with limbal melanoma.
30%
Approximately ____% of canine intraocular melanomas are benign,
and 95% arise from the ____ or _____.
75%
iris or ciliary body
Benign anterior uveal melanomas/melanocytomas have
________ mitotic figures/10 HPFs,
and malignant tumors demonstrate nuclear pleomorphism and a
mitotic index of at least ____ and often more than ____.
2-4/10hpf
4; >30
The overall rate of metastasis of intraocular melanomas is approxi-
mately ___% and usually occurs via the hematogenous route.
4%
In one study, approximately ___% of histologically malignant uveal melanomas demonstrated metastasis, typically within _____ of enucleation, and most dogs with metastasis were euthanized within ____ of enucleation.
25%
3 months
6 months
What is the most common primary intraocular tumor in cats?
anterior uveal melanoma
Cats with malignant uveal melanoma have a metastatic rate of ___ - ___%, frequently to the ___ and ____.
55-66% or higher
liver and lungs
What was associated with an increased and decreased risk of metastasis in cats with malignant uveal melanoma?
increased:
- extrascleral extension
- necrosis within the neoplasm
- mitotic index of >7/10hpf
- choroidal invasion
- increased labeling for E-cadherin or melan-A
decreased:
- PNL2 label homogeneity
What is the MST of uveal melanoma in cats with enucleation after ciliary body invasion but before scleral invasion?
5 years
What is the MST of uveal melanoma in cats with enucleation after both ciliary body and scleral invasion?
1.5 years
What is the second most common primary intraocular tumor of cats?
posttraumatic sarcoma
The latency period after trauma and intraocular sarcoma development in cats is ______.
5 years
Prognosis is better in cats with posttraumatic intraocular sarcoma when enucleation is performed before what?
tumor invades optic nerve or extends beyond sclera
___% of dogs with ocular lymphomas
are free of systemic disease at the time of enucleation and hence
were classified as presumed solitary ocular lymphoma (PSOL).
60%
Dogs with presumed solitary ocular lymphoma (PSOL) have a longer MST of ______ when treated with enucleation +/- chemotherapy than dogs with known systemic disease (MST ________).
26 months
3 months
In cats and dogs, _____% of orbital tumors are malignant, and regional
infiltration (including into the CNS) or distant metastasis is common or uncommon?
> 90%
common
Dogs younger than _____ diagnosed with orbital rhabdomyosarcoma had high rates of recurrence and/
or metastasis with MST of _____. In dogs _____ years of age or older
had a less aggressive biologic behavior with no clinical signs of recurrence or metastasis ____ - _____ postdiagnosis.
- 4 years
- MST 3 months
- 6 years
- 8-13 months
Radical orbitectomy (with or without chemotherapy or RT) provided a local disease-free interval of ______ in more than 50% of patients and a ____% survival rate for the first year.
> 1 year
70%
Mean survival time for cats with orbital tumors treated by RT, chemotherapy, or surgery that included resection of affected orbital bones was _____.
4 months
