Mammary Gland Tumors

Question 1

A retrospective case series of 107 cats having either unilateral mastectomy for mammary adenocarcinoma found a longer median progression-free ST of ______ for cats treated with bilateral mastectomies versus ________ for cats treated with unilateral mastectomy.

Answer 1

• bilateral PFS: 18 months
• unilateral PFS: 10 months

Question 2

In a retrospective case series comparing cats treated with surgery vs. surgery and adjuvant doxorubicin, the subset of cats having unilateral mastectomies followed with chemotherapy had significantly longer MSTs than cats having unilateral mastectomies without chemotherapy (_____ vs. _____). The recurrence rate was ____%.

Answer 2

• sx + chemo MST: 67 months (5.5 yrs)
• sx alone: 14 months
• 50%

Question 3

What is the range of MSTs in cats with grade 1, grade 2, and grade 3 mammary carcinoma using both grading systems?

Answer 3

• grade 1: 31-36 months
• grade 2: 14-18 months
• grade 3: 6-8 months

Question 4

Cats with mammary carcinomas <2cm treated with radical mastectomy have MST of ____. Tumors 2-3cm have MST ______. Tumors > 3cm MST _____.

Answer 4

• <2cm MST: > 3 years
• 2-3cm MST: 2 years
• > 3cm MST: 6 months

Question 5

A retrospective study with 92 cats found that all cats with LN metastasis died within _______ of diagnosis.

Answer 5

9 months

Question 6

Two cases series of cats with macroscopic primary mammary carcinoma and/or metastatic tumors found objective responses in ___ - ___% of the cats treated with combination of DOX and Cytoxan.

Answer 6

40-50%

Question 7

For mammary gland tumor histotypes, dogs with adenosquamous carcinoma have MST of _____, comedocarcinoma MST ______, solid carcinoma MST _______, and anaplastic carcinoma MST ______. Prolonged survival was observed for ______ and _______ types. A >10-fold higher risk of tumor-related death was associated with other certain types, such as _________, ________, and ________.

Answer 7

• adenosquamous MST: 18 months
• comedo MST: 14 months
• solid MST: 8 months
• anaplastic MST: 3 months
• Prolonged: complex carcinoma, simple tubular carcinoma
• hazard of death: simple tubulopapillary carcinoma, intraductal papillary carcinoma, and carcinoma and malignant myoepithelioma

Question 8

A retrospective study evaluating the outcome of 23 cats with mammary tumors that were treated with surgery, chemotherapy with doxorubicin, and meloxicam was published. What was the MST in this study?

Answer 8

15 months