T&H13 CSCs Flashcards
1
Q
Extracellular molecules, such as _____, ___, and _____ influence EMT.
A
TGFB
Wnt
PDGF
2
Q
What are markers of EMT?
A
- loss of E-cadherin
- upregulation of N-cadherin, S100A4, vimentin, smooth muscle actin, TWIST, SNAIL
3
Q
In EMT, polarized epithelial phenotype upregulate proteins that drive cell to …..
A
- reorganize cytoskeleton
- disconnect from ECM
- migrate
4
Q
Name 2 cancers in which malignant population predominates and 2 cancers in which stromal population predominates.
A
- malignant: LSA, melanoma
- stromal: pancreatic adenocarcinoma and Hodgkin LSA
5
Q
____ is a transmembrane receptor that allows cell to matrix anchorage
A
integrin
6
Q
____ is a type of cell adhesion molecule that allows cells to adhere to each other.
A
cadherin
7
Q
____ is an intracellular cytoplasmic protein that mediates adhesion of one cell to another by connecting actin microfilaments of one cell’s cytoskeleton to the transmembrane cadherins to another cell.
A
catenin
8
Q
What markers are used to identify CSCs?
A
CD133, CD44, ICAM1/CD54, and LGR5
9
Q
A
