W28-L8: Drugs to treat disorders of bone Flashcards
What stimulates osteoblasts?
Calcitriol (Vit.D) and PTH to express RANKL
What regulates the stimulation of osteoclasts?
OPG released by osteoblasts
What effect on bone remodelling does oestrogen have?
Decreased osteoclast activity
What effect on bone remodelling does glucocorticoids have?
Increased osteoclast and decrease osteoblast activity
What effect on bone remodelling do embedded cytokines have?
Increase osteoblast activity
What effect on bone remodelling does calcitonin have?
Decreased activity of osteoclasts
How does Vit. D (calcitriol) regulate bone mineralisation?
Increased plasma ca by increased intestinal absorption, decreased renal excretion
and increased osteoclast activity
How does PTH regulate bone mineralisation?
PTH by increasing calcitriol, mobilising calcium from bone, reducing renal ca excretion
How does calcitonin regulate bone mineralisation?
decreases osteoclast activity and Ca resorption from bone
What is osteopanenia?
Less severe form of osteoporosis
What are the two types of agents used in bone disorders?
Anti-resorptive and bone anabolic agents
What are bisphosphonates?
Anti-resorptive which Inhibit recruitment of osteoclasts and promotes apoptosis
How do bisphosphonates work?
taken up by bone and kill osteoclast when they try to eat it
like a mine
What is Raloxifene?
Anti-resorptive which is an Agonist at oestrogen receptors in bone and cardiovascular tissue
and Antagonist at oestrogen receptors in mammary tissue and uterus
What is Denosumab?
Anti-resorptive which is a RANKL inhibitor and reduces osteoclastic activity
