Vitamin-K

Question 1

Vitamin-K is a derivative of?

Answer 1

Napthoquinone.

Question 2

Another name of Vitamin-K ?

Answer 2

Phylloquinone.

Question 3

Synthetic compound structurally similar and similar activity to that of vitamin-K?

Answer 3

Menadione.

Question 4

Which substance is important for absorption of vitamin-K?

Answer 4

Chylomicrons.

Question 5

Main source of vitamin-K?

Answer 5

Intestinal bacterial flora.

Question 6

Which substance is transported to plasma from liver with vitamin-K?

Answer 6

Beta-lipoproteins.

Question 7

Which coagulation factors are dependent on vitamin-K?

Answer 7

2- prothrombin
7-Scpa
9-Christmas factor
10-Stuart power factor

Question 8

Why osteocalcin is both vitamin K and C dependent?

Answer 8

Bcoz it has hydroxyproline.

Question 9

Which microsomal enzyme requires Reduced vitamin-K?

Answer 9

Vitamin-K dependent carboxylase.

Question 10

Daily requirement of vitamin-K?

Answer 10

50-100mg/day.

Question 11

Reduced vitamin-K converted to Epoxide form of vitamin-K to Oxidised vitamin-K. Name that 3 converting enzymes?

Answer 11

1) O2+NADPH.
2) Epoxide reductase. ( reduced lipoic acid to oxidised lipoic acid)
3) Vitamin-K reductase.

Question 12

Formation of Epoxide form of vitamin-K to Oxidised vitamin-K is inhibited by?

Answer 12

Warfarin and Dicoumarol.

Question 13

Production of reduced vitamin-K from Oxidised vitamin-K is inhibited by?

Answer 13

Dicoumarol.

Question 14

In which case, foetal bone abnormalities occurs on treatment of pregnant women with warfarin?

Answer 14

Foetal warfarin syndrome.