Vitamin-D. Flashcards
Another name of vitamin-D?
Sunshine vitamin.
Name of vitamin-D3 and vitamin-D2?
Vitamin D3- cholecalciferol.
Vitamin D2- ergo calciferol.
Which vitamin is formed naturally and how?
Vitamin D3
Formed when UV rays falls on skin which has 7-dehydrocholestrol.
In liver, vitamin D3 to 25-hydroxycholecalciferol ,done by enzyme?
25- hydroxylase.
Which reaction is held by 1- alpha hydroxylase in kidney?
25-HCC to 1,25- DiHCC.
1,25- DiHCC also known as?
Calcitriol.
Reabsorption of which 2 substance are increased by calcitriol from renal tubules?
Calcium and phosphorus.
How absorption of calcium is increased by vitamin D3 in intestine?
By formation of calbindin. That binds with calcium and transport it to blood.
Which disease are cause due to deficiency of vitamin D3?
Rickets in children.
Osteomalacia in adults.
Major features of rickets?
1) Bowed legs.
2) Pigeon chest.
3) Ricket rosary.
4) Harrison sulcus.
Which abnormalities are seen in biochemical parameters of osteomalacia ?
1) Low serum calcium.
2) Low serum phosphate.
Ricket rosary?
Enlargement of epiphysis at lower ribs and costachondral junction.
In which type of rickets,defective renal tubular reabsorption of phosphate occurs?
Hypophoshatemic rickets.
In which type of Ricket , malabsorption of bicarbonate,A.A,phosphate,glucose occurs from renal tubules?
Vitamin D resistant Rickets
Vitamin D resistant ricket is found to be similar with which syndrome?
Fanconi syndrome.
