Vitamin-B1.

Question 1

Another name of vitamin-B1?

Answer 1

Thiamine.

Question 2

Rich source of Vitamin-B1?

Answer 2

Aleurone layer of cereals( unpolished grains).

Question 3

Chemical structure of vitamin-B1?

Answer 3

Pyramidine ring and Thiozole ring connected by methylene bridge.

Question 4

How is its inactive form is converted to active?

Answer 4

By adding 2 phosphates in presence of Thiamine pyrophosphotransferase.

Question 5

In which 4 mechanisms Thiamine pyrophosphate works as a coenzyme?

Answer 5

1) Carbohydrate metabolism.
2) By transketolase in HMP shunt pathway.
3) Breakdown of Pyruvate to Acetyl Co-A.
4) Oxidative decarboxylation of alpha KG to Succinyl Co-A.

Question 6

Which lipid soluble acylated derivative is used for diabetics?

Answer 6

Benfotiamine.

Question 7

Deficiency of vitamin-B1 leads to a common disease?

Answer 7

Beriberi.

Question 8

In which case, Cardiovascular manifestations are prominent?

Answer 8

Wet beriberi.

Question 9

In which case, CNS manifestations are prominent?

Answer 9

Dry beriberi.

Question 10

Which disease occurs in infants if mother is suffering from thiamine deficiency?

Answer 10

Infantile beriberi.

Question 11

Which disease has same clinical features as encephalopathy?

Answer 11

Wernicke korsakoff syndrome.

Question 12

Wernicke korsakoff syndrome also known as ?

Answer 12

Cerebral beriberi.

Question 13

Which disease will lead to lactic acidosis?

Answer 13

Polyneuritis.

Question 14

Polyneuritis is common in which type of patients?

Answer 14

Chronic alcoholics.

Question 15

Daily requirement?

Answer 15

1-1.5mg/day.