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Biochem final > Vitamin D > Flashcards

Vitamin D Flashcards

1
Q

major active form of vitamin D

A

1,25(OH)2D

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2
Q

the main form of plasma vitamin D

A

25(OH)D

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3
Q

enzyme that hydroxylates D2/D3 to 25(OH)D

A

25-hydroxylase

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4
Q

enzyme that metabolizes 25(OH)D to 1,25(OH)2D

A

1a-hydroxylase

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5
Q

physiological activity of 1,25(OH)2D in intestine

A

increase Ca and PO4 absorption

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6
Q

physiological activity of 1,25(OH)2D in bone

A

stimulate bone mineralization

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7
Q

physiological activity of 1,25(OH)2D in kidney

A

increase reabsorption of Ca and PO4

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8
Q

regulators of 1,25(OH)2D production

A

PTH, Ca, and PO4 via 1a-hydroxylase

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9
Q

hypocalcemia increases synthesis of 1,25(OH)2D by

A

stimuating PTH production

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10
Q 
skeletal deformities
frequent fractures
disturbed growth
tetany
generalized muscular weakness
A

Rickets

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11
Q

bone pain
muscular weakness
gradual softening and bending o fbones
fracture

A

osteomalacia

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Biochem final (10 decks)

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