Therapeutic drug monitoring

Question 1

the percentage of the original drug dose that is absorbed and passes through the liver unmetabolized

Answer 1

bioavailability

Question 2

what is measured to estimate clinical response

Answer 2

total plasma drug concentration

Question 3

time to reach steady state

Answer 3

five half lives

Question 4

average concentration at the therapeutic level is given by:

Answer 4

1.44t (1/2)D/VdT

Question 5

We sample at:

Answer 5

steady state
OR
Before next dose is given

Question 6

an anticonvulsant

Answer 6

Phenytoin

Question 7

an antiarrhythmic with a narrow therapeutic range

Answer 7

Digoxin

Question 8

at steady state the concentration of digoxin in cardiac tissues is how many times that of serum?

Answer 8

15-30

Question 9

tissue concentration of digoxin peaks how many hours after dosage

Answer 9

6-10

Question 10

therapeutic range of dioxin is determined by:

Answer 10

peaks

Question 11

an IV antibiotic

Answer 11

Aminoglycerides

Question 12

Immunosuppressive drugs are usually

Answer 12

administered in combination but at lower doses of each

Question 13

TDM for immunosuppressive drugs

Answer 13

immunoassay or GC/MS/MS

Question 14

Cyclosporine is

Answer 14

immunosuppressive drug

Question 15

Tacrolimus

Answer 15

immunosuppressive drug

Question 16

Sirolimus

Answer 16

immunosuppressive drug

Question 17

Myocophenolic acid

Answer 17

immunosuppressive drug