Vitamin B5 - Pantothenic acid

Question 1

origin of B5

Answer 1

plant: green vegetables, grains: pantothenic acid
animal: liver, egg, meat, milk: HS-CoA (hydrolysed to PA)

Question 2

how is B5 transported

Answer 2

passive to the liver, from liver:

• PA: passive tp to all organs
• HS-CoA: leave liver thorugh active tp.

Question 3

biochemical roles

Answer 3

1. Carrier of acyl group
2. forming thiolesters -> high energy bond
   ((R-COOH -> R-CO-S-CoA),water is given off acid)

Question 4

thiolester bond energy

Answer 4

-deltaG = -31.48kJ/mol

Question 5

most important acids bound to CoA

Answer 5

1. Acetyl-CoA
2. acetoacetyl-CoA
3. amino acyl-CoA
4. fatty acyl-CoA
5. malonyl-CoA
6. methylmalonyl-CoA
7. propionyl-CoA
8. butyryl-CoA
9. succinyl-CoA
10. HMG-CoA

Question 6

needed for activation of B5

Answer 6

4ATP + cysteine + CO2

Question 7

general deficiency: species esp. affected

Answer 7

(affect intermed. metabolism -> variety of damages)
anemia (decr. heme synth), slow growth in non-ru
Rat, chicken, pig,

Question 8

rat

Answer 8

hair loss

Question 9

chicken

Answer 9

chicken pellagra (dermatitis, diarrhea)

Question 10

pig

Answer 10

neuromuscular damage, “goose stepping”, weird movement