viruses general classification DNA

Question 1

Which DNA is ss?

Answer 1

Parvoviridae

Question 2

Which DNA are circular? 3

Answer 2

Polyomaviridae, papillomaviridae, hepadnaviridae

Question 3

Parvoviridae what virus?

Answer 3

DNA ss, naked

Question 4

which DNA is complex (all other are icosahedral)?

Answer 4

Poxviridae

Question 5

Which DNA virus replicates in cytoplasm?

Answer 5

Poxviridae

Question 6

Poxviridae where replicates?

Answer 6

in cytoplasm

Question 7

where replicates all DNA viruses except poxviridae?

Answer 7

in nucleus

Question 8

Polyomaviridae, papillomaviridae, hepadnaviridae nucleic. acid form?

Answer 8

circular

Question 9

what DNA are naked?4

Answer 9

parvo, polyoma, papilloma, adenovirus

Question 10

what DNA are enveloped? 2

Answer 10

hepadnaviridae, herpesviridae
FA kad ir poxvirus, bet UW - kad complex coat.

Question 11

Parvoviridae?

Answer 11

DNA, icosahedral, naked, ss

Question 12

Polyomaviridae?

Answer 12

DNA, icosahedral, naked, ds circular

Question 13

Papillomaviridae?

Answer 13

DNA, icosahedral, naked, ds circular

Question 14

Adenovirus?

Answer 14

DNA, icosahedral, naked, ds

Question 15

Hepadnaviridae?

Answer 15

DNA, icosahedral, enveloped, ds circular

Question 16

Herpesviridae?

Answer 16

DNA, icosahedral, enveloped, ds

Question 17

Poxviridae?

Answer 17

DNA, complex, complex coat, ds, replicates in cytoplasm

Question 18

Herpes virus. types

Answer 18

HSV1 ir HSV2

Question 19

HSV1 diseases?

Answer 19

gingivostomatitis, keratoconjuctivitis, herpes labialis, HERPETIC WHITLOW ON FINGER (in dentists especially), TEMPORAL LOBE ENCEPHALITIS, esophagitis, erythema multiforme

Question 20

HSV1. How spread virus to cause temporal encephalitis?

Answer 20

down the olfactory tract -> olfactory cortex in temporal lobe.

Question 21

HSV1. where latent?

Answer 21

in trigeminal ganglia

Question 22

HSV1. Brain?

Answer 22

Most common cause of sporadic encephalitis. Present as altered mental status, seizures, and/or aphasia.

Question 23

HSV2. diseases?

Answer 23

Herpes genitalis, neonatal herpes.

Question 24

HSV2. Latent where?

Answer 24

In sacral ganglia.

Question 25

HSV1 transmission?

Answer 25

respiratory secretions, saliva

Question 26

HSV2 transmission?

Answer 26

sexual contact, perinatal

Question 27

Which DNA virus is the largest?

Answer 27

Poxvirus

Question 28

Poxvirus diseases?

Answer 28

Varicella zoster (chirckenpox, shingles), encephalitis, pneumonia.

Question 29

Varicela hoster virus name?

Answer 29

HHV3

Question 30

What cause reactivation of HHV3?

Answer 30

age, trauma, malignancy, immunosupression

Question 31

Most common complication of shingles?

Answer 31

post-herpetic neuralgia

Question 32

HHV3 latent?

Answer 32

In dorsal root of cutaneous sensory neuron OR trigeminal ganglia.
CN V1 branch -> herpes zoster ophthalmicus.

Question 33

HHV3 transmision?

Answer 33

Resp secretions, contact with fluid from vesicles.

Question 34

Epstein bar virus (HHV4). diseases?

Answer 34

Mononucleosis

Question 35

mononucleosis presentation?

Answer 35

fever, hepatosplenomegaly, pharyngitis, lymphadenopathy (esp. posterior cervical nodes).

Question 36

Epstein bar virus (HHV4). assoc with what 3 malignancies?

Answer 36

Endemic (aka african) burkitt limphoma; nasopharyngeal carcionoma (esp. asian adults), lymphoproliferative diease in transplant patients.

Question 37

Epstein bar virus (HHV4) infects B cell throught?

Answer 37

CD21

Question 38

Epstein bar virus (HHV4). what test positive?

Answer 38

Positive monospost test - heterophile antibodies detected by agglutination of sheep or horse RBCs.

Question 39

Epstein bar virus (HHV4). transmission?

Answer 39

resp. secretions, saliva (aka kissing disease)

Question 40

Cytomegalus virus (HHV5). transmission?

Answer 40

CONGENITAL, transfusion, sexual contact, saliva, urine, transplant

Question 41

Cytomegalus virus (HHV5). monospot test?

Answer 41

negative (in comparison to EBV).

Question 42

Cytomegalus virus (HHV5). diseases?

Answer 42

mononucleosis (monospot negative) in IMMUNOCOMPETENT;
Infection in immunocompromised - pneumonia in transplant;
esophagitis; AIDS;
RETHINITIS - hemorrhage, cotton-wool exudates, vision loss.

CONGENITAL CMV

Question 43

Cytomegalus virus (HHV5). On biopsy?

Answer 43

Infected cells have characteristic ,,owl eye” intraNUCLEAR inclusions

Question 44

HHV6-7. transmission?

Answer 44

saliva

Question 45

HHV6-7. disease?

Answer 45

Roseola infantum (exanthem subitum): high fevers for several days that can cause seizures, followed by diffuse macular rash (trunk -> to extremities).

Question 46

HHV8. Transmission?

Answer 46

sexual contact

Question 47

HHV8. disease?

Answer 47

Kaposi sarcoma (neoplasm of ENDOTHELIAL cells)

Question 48

HHV8. in what patients?

Answer 48

HIV/AIDS and transplant patients

Question 49

Pox virus what skin disease?

Answer 49

Molluscum contagiosum

Question 50

Hepadnavirus - what disease?

Answer 50

HBV -> acute or chronic hepatitis
Not a retrovirus, but has reverse transcriptase

Question 51

Adenovirus - 6 diseases?

Answer 51

Febrile pharyngitis - sore throat
Acute hemorrhagic cystitis
Pneumonia
Conjuctivitis ,, pink eye”
Gastroenteritis
Myocarditis

Question 52

Papillomavirus - disease?

Answer 52

HPV warts - 1,2,6, 11
CIN 16, 18

Question 53

Polyomavirus - diseases?

Answer 53

JC virus - progressive multifocal leukoencephalopathy in HIV
BK virus - transplant patients, commonly targets kidney

Question 54

Parvovirus ->?

Answer 54

B19 - aplastic crises in sicle cell disease,, slapped cheek rash in kids (erythema infectosom or fifth disease”
Infects RBC precursors and endothelial cells

RBC destruction leads to pure RBC aplasia and RA-like symptoms